Lanthanide-dependent methanol dehydrogenase

Lanthanide-dependent methanol dehydrogenase
The enzyme as folded by AlphaFold
Identifiers
EC no.	1.1.2.10
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Lanthanide-dependent methanol dehydrogenase^[a] is an oxidoreductase enzyme involved in methane metabolic pathways in microbial metabolism. This enzyme was first isolated from the methylacidiphilum fumariolicum and others in the methylacidiphilum species. The enzyme requires La³⁺, Ce³⁺, Pr³⁺ or Nd³⁺. Higher lanthanides show decreasing activity with Sm³⁺, Eu³⁺ and Gd³⁺. The lanthanide atom in the enzyme is coordinated by pyrroloquinoline quinone.^[1] The enzyme catalyzes the following reaction

2 Fe(III)-cytochrome cL + methanol = 2 Fe(II)-cytochrome cL + formaldehyde + 2 H⁺

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