Lateral force transmission in skeletal muscle

A key component in lateral force transmission in skeletal muscle is the extracellular matrix (ECM). Skeletal muscle is a complex biological material that is composed of muscle fibers and an ECM consisting of the epimysium, perimysium, and endomysium. It can be described as a collagen fiber-reinforced composite. The ECM has at least three functions: (1) to provide a framework binding muscle fibers together and ensure their proper alignment, (2) to transmit the forces, either from active muscle contraction or ones passively imposed on it, and (3) providing lubricated surfaces between muscle fibers and bundles enabling the muscle to change shape.^[1] The mechanical properties of skeletal muscle depend on both the properties of muscle fibers and the ECM, and the interaction between the two. Contractile forces are transmitted laterally within intramuscular connective tissue to the epimysium and then to the tendon. Due to the nature of skeletal muscle, direct measurements are not possible, but many indirect studies and analyses have shown that the ECM is an important part of force transmission during muscle contraction.^{[2][3][4][5][6][7][8]}