List of 500cc/MotoGP riders who set a fastest lap

Grand Prix motorcycle racing is the premier championship of motorcycle road racing, which has been divided into four classes since 2023: MotoGP, Moto2, Moto3, and MotoE. Classes that have been discontinued include 500cc (although 500cc statistics are combined with MotoGP officially), 350cc, 250cc, 125cc, 80cc, 50cc and Sidecar. The Grand Prix Road-Racing World Championship was established in 1949 by the sport's governing body, the Fédération Internationale de Motocyclisme (FIM), and is the oldest motorsport World Championship.^[1]

Valentino Rossi holds the record for the most race fastest laps recorded in the premier 500cc/MotoGP class with 76. Giacomo Agostini is second with 69 fastest laps, and Marc Márquez is third with 59 fastest laps.^[2]