List of Spider-Man enemies

Spider-Man is a superhero created by Marvel Comics who debuted in the anthology comic book series issue Amazing Fantasy #15 (August 1962) during the Silver Age of Comics. After his debut, he received his own comic book entitled The Amazing Spider-Man. This comic introduced many of what would become his major supervillain adversaries. Spider-Man then became popular enough for more Spider-Man comic spinoffs (The Spectacular Spider-Man, Marvel Team-Up, Web of Spider-Man, Peter Parker: Spider-Man etc.) which introduced more recurring enemies of the web-slinger, across their various incarnations.

As with Spider-Man, most of his villains' powers originate from scientific accidents or the misuse of scientific technology. They can be classified into multiple categories, such as animal-themed villains (Doctor Octopus, Vulture, Black Cat, Lizard, Rhino, Scorpion, Jackal, Beetle, Kangaroo, Tarantula, and Puma), villains with powers over the elements (Sandman, Electro, Molten Man, and Hydro-Man), horror-themed villains (the Green Goblin, the Hobgoblin, Morbius, Morlun, and the Symbiotes), crime lords (the Kingpin, Tombstone, Hammerhead, Silvermane, and Mister Negative),^[1] inventors (the Shocker, the Tinkerer, Spencer Smythe, and Alistair Smythe), and masters of trickery and illusion (the Chameleon and Mysterio).^[1] There are, however, numerous villains that don't fit into any specific category, such as Kraven the Hunter and Mephisto, the latter of whom originated as a Silver Surfer villain. The villains oftentimes form teams such as the Sinister Six to oppose the web-slinger.

Spider-Man is notable for having numerous villains that redeemed themselves and became antiheroes, such as Black Cat, the Prowler, Morbius, Kraven, Sandman and Silver Sable. Also, unlike most superheroes, Spider-Man doesn't have one particular archenemy, but rather three: the Norman Osborn version of the Green Goblin, the Otto Octavius version of Doctor Octopus, and the Eddie Brock version of Venom, the latter two of whom have been similarly redeemed and depicted as antiheroes; since the late 2000s, the demon Mephisto has additionally been depicted as an overarching archenemy/prominent adversary of all incarnations of Spider-Man, responsible for Harry and Norman Osborn's transformations into the Green Goblin, creating Kindred, and manipulating various incarnations of Spider-Man into making deals with him: erasing Peter Parker's and Mary Jane Watson's marriage (and future daughter) from history, reverting Octavius from the Superior Spider-Man to a return to villainy, and tricking Miles Morales into sacrificing an innocent soul.

The rogues gallery of Spider-Man has garnered positive critical acclaim and has been considered one of the greatest rogues galleries of all time.