Lithium orotate

Lithium orotate

Clinical data
AHFS/Drugs.com	Monograph
Routes of administration	Oral
Legal status
Legal status	In general: Over-the-counter (OTC)
Identifiers
CAS Number	5266-20-6 Y
PubChem CID	23686432
ChemSpider	71254 N
UNII	L2N7Z24B30
CompTox Dashboard (EPA)	DTXSID9063748
ECHA InfoCard	100.023.711
Chemical and physical data
Formula	C5H3LiN2O4
Molar mass	162.03 g·mol−1
3D model (JSmol)	Interactive image
SMILES [Li+].O=C([O-])\C1=C\C(=O)NC(=O)N1
InChI InChI=1S/C5H4N2O4.Li/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);/q;+1/p-1 N Key:IZJGDPULXXNWJP-UHFFFAOYSA-M N
NY (what is this?)  (verify)

Lithium orotate (C₅H₃LiN₂O₄) is a salt of orotic acid and lithium. It is available as the monohydrate, LiC₅H₃N₂O₄·H₂O.^[1] In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissociates in solution to produce free lithium ions. It is marketed as a dietary supplement, though it has been researched minimally between 1973–1986 to treat certain medical conditions, such as alcoholism^[2] and Alzheimer's disease.

While lithium orotate is capable of providing lithium to the body,^[3] like lithium carbonate and other lithium salts, there are no systematic reviews supporting the efficacy of lithium orotate and it is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any medical condition.