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Clinical data | |
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Trade names | Claritin, Claratyne, Clarityn, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697038 |
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Routes of administration | By mouth |
Drug class | Second-generation antihistamine |
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Pharmacokinetic data | |
Bioavailability | almost 100% |
Protein binding | 97–99% |
Metabolism | Liver (CYP2D6- and 3A4-mediated) |
Elimination half-life | 8 hours, active metabolite desloratadine 27 hours |
Excretion | 40% as conjugated metabolites into urine Similar amount into the feces |
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ECHA InfoCard | 100.120.122 |
Chemical and physical data | |
Formula | C22H23ClN2O2 |
Molar mass | 382.89 g·mol−1 |
3D model (JSmol) | |
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Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies.[5] This includes allergic rhinitis (hay fever) and hives.[5] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant.[5] It is taken orally.[5]
Common side effects include sleepiness, dry mouth, and headache.[5] Serious side effects are rare and include allergic reactions, seizures, and liver problems.[6] Use during pregnancy appears to be safe but has not been well studied.[7] It is not recommended in children less than two years old.[6] It is in the second-generation antihistamine family of medication.[5]
Loratadine was patented in 1980 and came to market in 1988.[8] It is on the World Health Organization's List of Essential Medicines.[9] Loratadine is available as a generic medication.[5][10] In the United States, it is available over the counter.[5] In 2021, it was the 67th most commonly prescribed medication in the United States, with more than 9 million prescriptions.[11][12]
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