Lucrezia de' Medici, Duchess of Ferrara

Lucrezia de' Medici
Portrait attributed to Bronzino or Alessandro Allori, ca. 1560
Duchess consort of Ferrara
Tenure	3 October 1559 – 21 April 1561
Duchess consort of Modena and Reggio
Tenure	3 October 1559 – 21 April 1561
Born	(1545-02-14)14 February 1545 Florence, Republic of Florence
Died	21 April 1561(1561-04-21) (aged 16) Ferrara, Duchy of Ferrara
Burial	Corpus Domini, Ferrara
Spouse	Alfonso II d'Este, Duke of Ferrara, Modena and Reggio ​ ​ (m. 1558)​
House	Medici (by birth) Este (by marriage)
Father	Cosimo I de' Medici, Grand Duke of Tuscany
Mother	Eleanor of Toledo

Lucrezia de' Medici (14 February 1545 – 21 April 1561) was a member of the House of Medici and by marriage Duchess consort of Ferrara, Modena and Reggio from 1558 to 1561.

Married to the intended husband of her elder sister Maria, who died young, her marriage was short and unhappy. The Duchess died of pulmonary tuberculosis, but almost immediately after her death there were rumors that she had been poisoned on the orders of her husband. That suspicion inspired the English poet Robert Browning to create a dramatic monologue in verse "My Last Duchess" (1842).