MAPK1

MAPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I
Identifiers
Aliases	MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1, NS13
External IDs	OMIM: 176948; MGI: 1346858; HomoloGene: 37670; GeneCards: MAPK1; OMA:MAPK1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,867,680 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,865,317 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; postcentral gyrus; ; Brodmann area 23; ; entorhinal cortex; ; superior frontal gyrus; ; external globus pallidus; ; Pons; ; visceral pleura; ; skin of thigh; ; skin of hip;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; olfactory tubercle; ; superior frontal gyrus; ; primary visual cortex; ; entorhinal cortex; ; perirhinal cortex; ; hippocampus proper; ; CA3 field; ; Amygdala; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; ATP binding; protein kinase activity; transcription factor binding; transferase activity; mitogen-activated protein kinase kinase kinase binding; phosphotyrosine residue binding; protein binding; protein kinase binding; DNA binding; nucleotide binding; RNA polymerase II CTD heptapeptide repeat kinase activity; protein serine/threonine kinase activity; kinase activity; identical protein binding; MAP kinase activity; double-stranded DNA binding; MAP kinase kinase activity;
Cellular component	cytoplasm; cytosol; focal adhesion; microtubule organizing center; mitochondrion; caveola; dendrite cytoplasm; cytoskeleton; nucleus; extracellular exosome; perikaryon; late endosome; Golgi apparatus; spindle; axon; early endosome; mitotic spindle; pseudopodium; extracellular region; nucleoplasm; azurophil granule lumen; ficolin-1-rich granule lumen; plasma membrane; postsynaptic density; membrane; protein-containing complex;
Biological process	caveolin-mediated endocytosis; positive regulation of telomere capping; response to exogenous dsRNA; cardiac neural crest cell development involved in heart development; positive regulation of translation; cellular response to DNA damage stimulus; platelet activation; Fc-epsilon receptor signaling pathway; protein phosphorylation; face development; cellular response to granulocyte macrophage colony-stimulating factor stimulus; regulation of DNA-binding transcription factor activity; animal organ morphogenesis; cell cycle; ERBB signaling pathway; apoptotic process; B cell receptor signaling pathway; regulation of transcription, DNA-templated; regulation of protein stability; Fc-gamma receptor signaling pathway involved in phagocytosis; thymus development; negative regulation of cell differentiation; ERK1 and ERK2 cascade; labyrinthine layer blood vessel development; transcription, DNA-templated; positive regulation of transcription, DNA-templated; heart development; viral process; response to toxic substance; regulation of stress-activated MAPK cascade; chemical synaptic transmission; growth hormone receptor signaling pathway via JAK-STAT; cytosine metabolic process; phosphorylation; outer ear morphogenesis; response to estrogen; chemotaxis; response to lipopolysaccharide; thyroid gland development; response to epidermal growth factor; positive regulation of telomerase activity; sensory perception of pain; peptidyl-threonine phosphorylation; trachea formation; lipopolysaccharide-mediated signaling pathway; mammary gland epithelial cell proliferation; intracellular signal transduction; lung morphogenesis; neural crest cell development; positive regulation of cell migration; regulation of early endosome to late endosome transport; response to stress; positive regulation of telomere maintenance via telomerase; MAPK cascade; axon guidance; fibroblast growth factor receptor signaling pathway; positive regulation of peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; regulation of cellular response to heat; Bergmann glial cell differentiation; regulation of Golgi inheritance; T cell receptor signaling pathway; regulation of cytoskeleton organization; signal transduction; long-term potentiation; regulation of ossification; regulation of phosphatidylinositol 3-kinase signaling; neutrophil degranulation; regulation of gene expression; cellular response to organic substance; ageing; learning or memory; positive regulation of gene expression; diadenosine tetraphosphate biosynthetic process; regulation of cellular pH; cellular response to amino acid starvation; cellular response to reactive oxygen species; response to nicotine; decidualization; stress-activated MAPK cascade; positive regulation of cardiac muscle cell proliferation; cellular response to cadmium ion; cellular response to tumor necrosis factor; cellular response to dopamine; positive regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	5594
	26413
	ENSG00000100030
	ENSMUSG00000063358
	P28482
	P63085
	NM_138957; NM_002745
	NM_001038663; NM_011949; NM_001357115; NM_028991
	NP_002736; NP_620407
	NP_001033752; NP_036079; NP_001344044
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100030 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063358 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Owaki H, Makar R, Boulton TG, Cobb MH, Geppert TD (February 1992). "Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs". Biochem. Biophys. Res. Commun. 182 (3): 1416–22. doi:10.1016/0006-291X(92)91891-S. PMID 1540184.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100030 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063358 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1540184-5] Owaki H, Makar R, Boulton TG, Cobb MH, Geppert TD (February 1992). "Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs". Biochem. Biophys. Res. Commun. 182 (3): 1416–22. doi:10.1016/0006-291X(92)91891-S. PMID 1540184.

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