MAPK6

MAPK6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I6L
Identifiers
Aliases	MAPK6, ERK3, HsT17250, PRKM6, p97MAPK, mitogen-activated protein kinase 6
External IDs	OMIM: 602904; MGI: 1354946; HomoloGene: 55683; GeneCards: MAPK6; OMA:MAPK6 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	52,067,375 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,317,287 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; gums; ; gingival epithelium; ; mucosa of ileum; ; hair follicle; ; cervix epithelium; ; middle temporal gyrus; ; Pons; ; skin of thigh; ; body of tongue;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; zygote; ; ganglionic eminence; ; somite; ; molar; ; mandibular prominence; ; medial ganglionic eminence; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding; protein kinase binding; protein heterodimerization activity; MAP kinase activity;
Cellular component	nucleoplasm; septin cytoskeleton; cytosol; nucleus; cytoplasm; protein-containing complex;
Biological process	protein phosphorylation; cell cycle; phosphorylation; signal transduction; MAPK cascade; positive regulation of dendritic spine development; regulation of gene expression; cellular response to organic substance; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5597
	50772
	ENSG00000069956
	ENSMUSG00000042688
	Q16659
	Q61532
	NM_002748
	NM_015806; NM_027418
	NP_002739
	NP_056621; NP_081694
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.^[5]^[6]

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases, also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069956 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042688 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Meloche S (2005-04-01). "Erk3". AfCS-Nature Molecule Pages. doi:10.1038/mp.a000876.01 (inactive 1 November 2024). ISSN 1477-5921.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
^ ^a ^b "MAPK6 mitogen-activated protein kinase 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-11-09.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069956 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042688 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Meloche S (2005-04-01). "Erk3". AfCS-Nature Molecule Pages. doi:10.1038/mp.a000876.01 (inactive 1 November 2024). ISSN 1477-5921.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)

[:0-6] "MAPK6 mitogen-activated protein kinase 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-11-09.

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