Macrophage-1 antigen

Macrophage-1 antigen (or integrin α_Mβ₂ or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin α_M) and CD18 (integrin β₂).^[1]

The integrin α chain is noncovalently bound to the integrin β chain. It binds to iC3b and can be involved in cellular adhesion, binding to the intercellular adhesion molecule-1 (ICAM-1).^[2]^[3] CR3 causes phagocytosis and destruction of cells opsonized with iC3b. CR3 and CR4 are thought to exhibit overlapping functions; however, the distinct binding sites to iC3b suggests differences in their functions.^[4] Additionally, CR3 has been shown to have therapeutic promise.^[5]^[6]^[7]

^ Todd R (1996). "The continuing saga of complement receptor type 3 (CR3)". J. Clin. Invest. 98 (1): 1–2. doi:10.1172/JCI118752. PMC 507390. PMID 8690779.
^ Abbas AK, Lichtman AH, Pillai S (2017-03-10). Cellular and Molecular Immunology (Ninth ed.). Philadelphia, PA. ISBN 978-0-323-52323-3. OCLC 973917896.{{cite book}}: CS1 maint: location missing publisher (link)
^ Ross GD, Vĕtvicka V (May 1993). "CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions". Clinical and Experimental Immunology. 92 (2): 181–4. doi:10.1111/j.1365-2249.1993.tb03377.x. PMC 1554824. PMID 8485905.
^ Erdei, Anna; Lukácsi, Szilvia; Mácsik-Valent, Bernadett; Nagy-Baló, Zsuzsa; Kurucz, István; Bajtay, Zsuzsa (2019). "Non-identical twins: Different faces of CR3 and CR4 in myeloid and lymphoid cells of mice and men" (PDF). Seminars in Cell & Developmental Biology. 85: 110–121. doi:10.1016/j.semcdb.2017.11.025. PMID 29174917. S2CID 6098102.
^ Hu, X.; Wohler, J. E.; Dugger, K. J.; Barnum, S. R. (2010-03-01). "2-Integrins in demyelinating disease: not adhering to the paradigm". Journal of Leukocyte Biology. 87 (3): 397–403. doi:10.1189/jlb.1009654. ISSN 0741-5400. PMC 3212424. PMID 20007244.
^ Joshi, Medha D.; Unger, Wendy J.; Storm, Gert; van Kooyk, Yvette; Mastrobattista, Enrico (2012). "Targeting tumor antigens to dendritic cells using particulate carriers". Journal of Controlled Release. 161 (1): 25–37. doi:10.1016/j.jconrel.2012.05.010. PMID 22580109.
^ Bednarczyk, Monika; Stege, Henner; Grabbe, Stephan; Bros, Matthias (2020-02-19). "β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease". International Journal of Molecular Sciences. 21 (4): 1402. doi:10.3390/ijms21041402. ISSN 1422-0067. PMC 7073085. PMID 32092981.

[1] Todd R (1996). "The continuing saga of complement receptor type 3 (CR3)". J. Clin. Invest. 98 (1): 1–2. doi:10.1172/JCI118752. PMC 507390. PMID 8690779.

[2] Abbas AK, Lichtman AH, Pillai S (2017-03-10). Cellular and Molecular Immunology (Ninth ed.). Philadelphia, PA. ISBN 978-0-323-52323-3. OCLC 973917896.{{cite book}}: CS1 maint: location missing publisher (link)

[3] Ross GD, Vĕtvicka V (May 1993). "CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions". Clinical and Experimental Immunology. 92 (2): 181–4. doi:10.1111/j.1365-2249.1993.tb03377.x. PMC 1554824. PMID 8485905.

[:0-4] Erdei, Anna; Lukácsi, Szilvia; Mácsik-Valent, Bernadett; Nagy-Baló, Zsuzsa; Kurucz, István; Bajtay, Zsuzsa (2019). "Non-identical twins: Different faces of CR3 and CR4 in myeloid and lymphoid cells of mice and men" (PDF). Seminars in Cell & Developmental Biology. 85: 110–121. doi:10.1016/j.semcdb.2017.11.025. PMID 29174917. S2CID 6098102.

[:1-5] Hu, X.; Wohler, J. E.; Dugger, K. J.; Barnum, S. R. (2010-03-01). "2-Integrins in demyelinating disease: not adhering to the paradigm". Journal of Leukocyte Biology. 87 (3): 397–403. doi:10.1189/jlb.1009654. ISSN 0741-5400. PMC 3212424. PMID 20007244.

[:2-6] Joshi, Medha D.; Unger, Wendy J.; Storm, Gert; van Kooyk, Yvette; Mastrobattista, Enrico (2012). "Targeting tumor antigens to dendritic cells using particulate carriers". Journal of Controlled Release. 161 (1): 25–37. doi:10.1016/j.jconrel.2012.05.010. PMID 22580109.

[:3-7] Bednarczyk, Monika; Stege, Henner; Grabbe, Stephan; Bros, Matthias (2020-02-19). "β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease". International Journal of Molecular Sciences. 21 (4): 1402. doi:10.3390/ijms21041402. ISSN 1422-0067. PMC 7073085. PMID 32092981.

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