Manuel Komnenos (1118–1180) was a Byzantine emperor.
Manuel Komnenos may also refer to:
- Manuel Erotikos Komnenos (955/960 – c. 1020), progenitor of the Komnenian dynasty
- Manuel Komnenos (kouropalates) (c. 1045 – 1071), older brother of Alexios I Komnenos
- Manuel Komnenos (son of Andronikos I) (1145–1185), eldest son of Andronikos I Komnenos and father of Alexios I of Trebizond
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