Mesenchymal stem cell

Mesenchymal stem cell
Mesenchymal stem cell
	Transmission electron micrograph of a mesenchymal stem cell displaying typical ultrastructural characteristics
Details
Identifiers
Latin	cellula mesenchymatica praecursoria
MeSH	D059630
TH	H2.00.01.0.00008
	Anatomical terms of microanatomy

Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).^[1]^[2]^[3]^[4]

The primary function of MSCs is to respond to injury and infection by secreting and recruiting a range of biological factors, as well as modulating inflammatory processes to facilitate tissue repair and regeneration. Extensive research interest has led to more than 80,000 peer-reviewed papers on MSCs.^[5]

^ Tonk CH, Witzler M, Schulze M, Tobiasch E (2020). "Mesenchymal Stem Cells". In Brand-Saberi B (ed.). Essential Current Concepts in Stem Cell Biology. Learning Materials in Biosciences. Cham: Springer International Publishing. pp. 21–39. doi:10.1007/978-3-030-33923-4_2. ISBN 978-3-030-33923-4. S2CID 214523766.
^ Ankrum JA, Ong JF, Karp JM (March 2014). "Mesenchymal stem cells: immune evasive, not immune privileged". Nature Biotechnology. 32 (3): 252–60. doi:10.1038/nbt.2816. PMC 4320647. PMID 24561556.
^ Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics". International Journal of Cell Biology. 2016: 6940283. doi:10.1155/2016/6940283. PMC 4969512. PMID 27516776.
^ Caplan AI (June 2017). "Mesenchymal Stem Cells: Time to Change the Name!". Stem Cells Translational Medicine. 6 (6): 1445–1451. doi:10.1002/sctm.17-0051. PMC 5689741. PMID 28452204.
^ Li Z, Hu X, Zhong JF (2019). "Mesenchymal Stem Cells: Characteristics, Function, and Application". Stem Cells Int. 2019: 8106818. doi:10.1155/2019/8106818. PMC 6431372. PMID 30956675.

[1] Tonk CH, Witzler M, Schulze M, Tobiasch E (2020). "Mesenchymal Stem Cells". In Brand-Saberi B (ed.). Essential Current Concepts in Stem Cell Biology. Learning Materials in Biosciences. Cham: Springer International Publishing. pp. 21–39. doi:10.1007/978-3-030-33923-4_2. ISBN 978-3-030-33923-4. S2CID 214523766.

[pmid24561556-2] Ankrum JA, Ong JF, Karp JM (March 2014). "Mesenchymal stem cells: immune evasive, not immune privileged". Nature Biotechnology. 32 (3): 252–60. doi:10.1038/nbt.2816. PMC 4320647. PMID 24561556.

[pmid27516776-3] Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics". International Journal of Cell Biology. 2016: 6940283. doi:10.1155/2016/6940283. PMC 4969512. PMID 27516776.

[Mesenchymal_Stem_Cells:_Time_to_Cha-4] Caplan AI (June 2017). "Mesenchymal Stem Cells: Time to Change the Name!". Stem Cells Translational Medicine. 6 (6): 1445–1451. doi:10.1002/sctm.17-0051. PMC 5689741. PMID 28452204.

[5] Li Z, Hu X, Zhong JF (2019). "Mesenchymal Stem Cells: Characteristics, Function, and Application". Stem Cells Int. 2019: 8106818. doi:10.1155/2019/8106818. PMC 6431372. PMID 30956675.

[1]

[2]

[3]

[4]

[5]