Back الميتاجينومية Arabic Metagenomika BS Metagenòmica Catalan Metagenomika Czech Metagenomik German Metagenómica Spanish متاژنومیک Persian Métagénomique French Metaxenómica Galician מטא-גנומיקה HE

Metagenomics

Part of a series on
Genetics
Key components
History and topics
Research
Fields
Personalized medicine
In metagenomics, the genetic materials (DNA, C) are extracted directly from samples taken from the environment (e.g. soil, sea water, human gut, A) after filtering (B), and are sequenced (E) after multiplication by cloning (D) in an approach called shotgun sequencing. These short sequences can then be put together again using assembly methods (F) to deduce the individual genomes or parts of genomes that constitute the original environmental sample. This information can then be used to study the species diversity and functional potential of the microbial community of the environment.[1]

Metagenomics is the study of genetic material recovered directly from environmental or clinical samples by a method called sequencing. The broad field may also be referred to as environmental genomics, ecogenomics, community genomics or microbiomics.

While traditional microbiology and microbial genome sequencing and genomics rely upon cultivated clonal cultures, early environmental gene sequencing cloned specific genes (often the 16S rRNA gene) to produce a profile of diversity in a natural sample. Such work revealed that the vast majority of microbial biodiversity had been missed by cultivation-based methods.[2]

Because of its ability to reveal the previously hidden diversity of microscopic life, metagenomics offers a powerful way of understanding the microbial world that might revolutionize understanding of biology.[3] As the price of DNA sequencing continues to fall, metagenomics now allows microbial ecology to be investigated at a much greater scale and detail than before. Recent studies use either "shotgun" or PCR directed sequencing to get largely unbiased samples of all genes from all the members of the sampled communities.[4]

  1. ^ Cite error: The named reference wooley2010 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Hugenholz1998 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference MarcoD2011 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Eisen2007 was invoked but never defined (see the help page).

Rich TVX News Network Site

Rich TVX News Network Info

© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search