Mianserin

Mianserin
Clinical data
Trade names	Tolvon, others
Other names	Mianserin hydrochloride; Org GB 94
Pregnancy; category	AU: B2; ;
Routes of; administration	By mouth
ATC code	N06AX03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	20–30%
Protein binding	95%
Metabolism	Liver (CYP2D6; via aromatic hydroxylation, N-oxidation, N-demethylation)
Elimination half-life	21–61 hours
Excretion	Urine: 4–7%; Feces: 14–28%
Identifiers
	IUPAC name (±)-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine;
CAS Number	24219-97-4 ; 21535-47-7 (hydrochloride); 51152-88-6 ((S)-isomer);
PubChem CID	4184;
IUPHAR/BPS	135;
DrugBank	DB06148 ;
ChemSpider	4040 ;
UNII	250PJI13LM;
KEGG	D08216 ;
ChEBI	CHEBI:51137 ;
ChEMBL	ChEMBL6437 ;
CompTox Dashboard (EPA)	DTXSID6023317 ;
ECHA InfoCard	100.041.884
Chemical and physical data
Formula	C18H20N2
Molar mass	264.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c42c(N3C(c1ccccc1C2)CN(C)CC3)cccc4;
	InChI InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 ; Key:UEQUQVLFIPOEMF-UHFFFAOYSA-N ;
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Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world.^[6] It is a tetracyclic antidepressant (TeCA). Mianserin is closely related to mirtazapine, both chemically and in terms of its actions and effects, although there are significant differences between the two drugs.^[7]

^ Cite error: The named reference IndexNominum2000 was invoked but never defined (see the help page).
^ Cite error: The named reference Drugs.com was invoked but never defined (see the help page).
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b ^c ^d ^e Truven Health Analytics, Inc. Drugdex System (Internet) [cited 2013 Sep 29]. Greenwood Village, CO: Thomsen Healthcare; 2013.
^ Cite error: The named reference TOLVON was invoked but never defined (see the help page).
^ "Mianserin 30 mg film-coated tablets". UK Electronic Medicines Compendium. January 2014. Retrieved 20 August 2017.
^ "A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin". Journal of pharmacy and pharmacology. Oxford University Press. April 2011. Retrieved 29 January 2022.

[IndexNominum2000-1] Cite error: The named reference IndexNominum2000 was invoked but never defined (see the help page).

[Drugs.com-2] Cite error: The named reference Drugs.com was invoked but never defined (see the help page).

[3] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[DD-4] Truven Health Analytics, Inc. Drugdex System (Internet) [cited 2013 Sep 29]. Greenwood Village, CO: Thomsen Healthcare; 2013.

[TOLVON-5] Cite error: The named reference TOLVON was invoked but never defined (see the help page).

[UKlabel-6] "Mianserin 30 mg film-coated tablets". UK Electronic Medicines Compendium. January 2014. Retrieved 20 August 2017.

[MirtazDiff-7] "A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin". Journal of pharmacy and pharmacology. Oxford University Press. April 2011. Retrieved 29 January 2022.

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