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Clinical data | |
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Trade names | Tolvon, others |
Other names | Mianserin hydrochloride; Org GB 94[1][2] |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 20–30%[4] |
Protein binding | 95%[4] |
Metabolism | Liver (CYP2D6; via aromatic hydroxylation, N-oxidation, N-demethylation)[4] |
Elimination half-life | 21–61 hours[5] |
Excretion | Urine: 4–7%[4] Feces: 14–28%[4] |
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ECHA InfoCard | 100.041.884 |
Chemical and physical data | |
Formula | C18H20N2 |
Molar mass | 264.372 g·mol−1 |
3D model (JSmol) | |
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Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world.[6] It is a tetracyclic antidepressant (TeCA). Mianserin is closely related to mirtazapine, both chemically and in terms of its actions and effects, although there are significant differences between the two drugs.[7]
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