The microbiota are the sum of all symbiotic microorganisms (mutualistic, commensal or pathogenic) living on or in an organism. The fruit fly Drosophila melanogaster is a model organism and known as one of the most investigated organisms worldwide. The microbiota in flies is less complex than that found in humans. It still has an influence on the fitness of the fly,[1] and it affects different life-history characteristics such as lifespan (life expectancy), resistance against pathogens (immunity) and metabolic processes (digestion). Considering the comprehensive toolkit available for research in Drosophila, analysis of its microbiome could enhance our understanding of similar processes in other types of host-microbiota interactions, including those involving humans. Microbiota plays key roles in the intestinal immune and metabolic responses via their fermentation product (short chain fatty acid), acetate.[2]
- ^ Gould AL, Zhang V, Lamberti L, Jones EW, Obadia B, Korasidis N, et al. (December 2018). "Microbiome interactions shape host fitness". Proceedings of the National Academy of Sciences of the United States of America. 115 (51): E11951–E11960. Bibcode:2018PNAS..11511951G. doi:10.1073/pnas.1809349115. PMC 6304949. PMID 30510004.
- ^ Jugder, Bat-Erdene; Kamareddine, Layla; Watnick, Paula I. (2021). "Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex". Immunity. 54 (8): 1683–1697.e3. doi:10.1016/j.immuni.2021.05.017. ISSN 1074-7613. PMC 8363570. PMID 34107298.
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