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Mobilome

(A) Transposable elements are flanked by inverted tandem repeats (TIRs). (B) Transposases cleave the transposable element at the TIRs. The free transposable element inserts into another part of the genome.

The mobilome is the entire set of mobile genetic elements in a genome. Mobilomes are found in eukaryotes,[1] prokaryotes,[2] and viruses.[3] The compositions of mobilomes differ among lineages of life, with transposable elements being the major mobile elements in eukaryotes, and plasmids and prophages being the major types in prokaryotes.[4] Virophages contribute to the viral mobilome.[5]

  1. ^ Hurst GD, Werren JH (August 2001). "The role of selfish genetic elements in eukaryotic evolution". Nature Reviews. Genetics. 2 (8): 597–606. doi:10.1038/35084545. PMID 11483984. S2CID 2715605.
  2. ^ Toussaint A, Merlin C (January 2002). "Mobile elements as a combination of functional modules". Plasmid. 47 (1): 26–35. doi:10.1006/plas.2001.1552. PMID 11798283.
  3. ^ Miller DW, Miller LK (October 1982). "A virus mutant with an insertion of a copia-like transposable element". Nature. 299 (5883): 562–4. Bibcode:1982Natur.299..562M. doi:10.1038/299562a0. PMID 6289125. S2CID 4275018.
  4. ^ Siefert JL (2009). "Defining the Mobilome". In Gogarten MB, Gogarten JP, Olendzenski LC (eds.). Horizontal Gene Transfer: Genomes in Flux. Methods in Molecular Biology. Vol. 532. Humana Press. pp. 13–27. doi:10.1007/978-1-60327-853-9_2. ISBN 9781603278539. PMID 19271177.
  5. ^ Bekliz M, Colson P, La Scola B (November 2016). "The Expanding Family of Virophages". Viruses. 8 (11): 317. doi:10.3390/v8110317. PMC 5127031. PMID 27886075.

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