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Monofluorophosphate

Monofluorophosphate
Structure of fluorophosphonate ion

Names
IUPAC name
Fluoro-dioxido-oxo-λ5-phosphane
Other names
  • Fluorophosphate
  • Fluorophosphonate
  • Monofluorophosphate
  • Phosphorofluoridate
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/FH2O3P/c1-5(2,3)4/h(H2,2,3,4)/p-2
    Key: DWYMPOCYEZONEA-UHFFFAOYSA-L
  • [O-]P(=O)([O-])F
Properties
PO3F2−
Molar mass 97.971 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Monofluorophosphate is an anion with the formula PO3F2−, which is a phosphate group with one oxygen atom substituted with a fluoride atom. The charge of the ion is −2. The ion resembles sulfate in size, shape and charge, and can thus form compounds with the same structure as sulfates. These include Tutton's salts and langbeinites. The most well-known compound of monofluorophosphate is sodium monofluorophosphate, commonly used in toothpaste.

Related ions include difluorophosphate (PO2F−2) and hexafluorophosphate ([PF6]−).[1] The related neutral molecule is phosphenic fluoride PO2F.

Organic derivatives can be highly toxic and include diisopropyl fluorophosphate. Some of the Novichok agents are monofluorophosphate esters. Names are given to these by naming the groups attached as esters and then adding "fluorophosphonate" to the end of the name. Two organic groups can be attached. Other related nerve gas substances may not be esters, and instead have carbon-phosphorus or nitrogen-phosphorus bonds. The organic fluorophosphonates react with serine esterases and serine proteases irreversibly. This prevents these enzymes from functioning. Such an important enzyme is acetylcholinesterase as found in most animals.[2] Some of the organic esters are detoxified in mammals by an enzyme in the blood and liver called paraoxonase PON1.[3]

Willy Lange from Berlin discovered sodium monofluorophosphate in 1929. He fruitlessly tried to make monofluorophosphoric acid. However, he did discover the highly toxic organic esters. Following this discovery various nerve gases like sarin were developed.

Fluorophosphate glasses are low melting point kinds of glass which are mixtures of fluoride and phosphate metal compounds. For example, the composition 10% SnO, 40% SnF2, 50% P2O5 forms a glass melting about 139 °C. PbO and PbF2 can lower the melting temperature, and increase water resistance.[4] These glasses can also be coloured by various other elements, and organic dyes.

Some mixed anion compounds are known with other anions like fluoride, chloride, difluorophosphate or tetrafluoroborate.

  1. ^ Cotton, F. Albert; Wilkinson, Geoffrey (1966). Advanced Inorganic Chemistry: A Comprehensive Text. John Wiley & Sons. p. 516.
  2. ^ Baynes, John W.; Dominiczak, Marek H. (2018). Medical Biochemistry E-Book. Elsevier Health Sciences. p. 72. ISBN 9780702073007.
  3. ^ Zech, Ronald; Chemnitius, JörgM. (2002). "PON1 in Different Species". Paraoxonase (PON1) in Health and Disease. Springer US. pp. 137–163. doi:10.1007/978-1-4615-1027-7_7. ISBN 9781461353584.
  4. ^ Shaw, Cathy M.; Shelby, James E. (1988). "Effect of Lead Compounds on the Properties of Stannous Fluorophosphate Glasses". Journal of the American Ceramic Society. 71 (5): C252–C253. doi:10.1111/j.1151-2916.1988.tb05071.x. ISSN 0002-7820.

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