Mural cells are the generalized name of cell population in the microcirculation that is comprised of vascular smooth muscle cells (vSMCs), and pericytes. Both types are in close contact with the endothelial cells lining the capillaries, and are important for vascular development and stability. The vasculature is a system of small, interconnected tubes that ensure there is proper blood flow to all of the organs.[1]Mural cells are involved in the formation of normal vasculature and are responsive to factors including platelet-derived growth factor B (PDGFB) and vascular endothelial growth factor (VEGF).[2][3] The weakness and disorganization of tumor vasculature is partly due to the inability of tumors to recruit properly organized mural cells.[4]
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