Muscimol

Muscimol

Names
IUPAC name 5-(Aminomethyl)-1,2-oxazol-3(2H)-one
Other names Agarin, Pantherine, Agarine, Pantherin
Identifiers
CAS Number	2763-96-4 Y
3D model (JSmol)	Interactive image
Beilstein Reference	774694
ChEBI	CHEBI:7035 Y
ChEMBL	ChEMBL273481 Y
ChemSpider	4116 Y
ECHA InfoCard	100.018.574
EC Number	220-430-4
IUPHAR/BPS	4259
KEGG	C08311 Y
PubChem CID	4266
UNII	D5M179TY2E Y
UN number	2811 3077
CompTox Dashboard (EPA)	DTXSID5041069
InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) Y Key: ZJQHPWUVQPJPQT-UHFFFAOYSA-N Y InChI=1/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) Key: ZJQHPWUVQPJPQT-UHFFFAOYAI
SMILES NCc1cc(no1)O
Properties[1]
Chemical formula	C4H6N2O2
Molar mass	114.104 g·mol−1
Melting point	184 to 185 °C (363 to 365 °F; 457 to 458 K)
Solubility in water	very soluble
Solubility in ethanol	slightly soluble
Solubility in methanol	very soluble
Pharmacology
Legal status	legal in most countries
Hazards
GHS labelling:[2]
Hazard statements	H300
Precautionary statements	P264, P270, P301+P316, P321, P330, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Muscimol is a potent psychoactive compound found in certain mushrooms, most notably the Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABA_A receptor^[3].

Muscimol, an agonist for the GABA_A receptor, was able to significantly alleviate pain in its peak effect, recent studies from 2023 show. Muscimol, through its potent interaction with GABA-A receptors, exerts significant effects on the central nervous system. Its ability to enhance inhibitory neurotransmission and protect neurons from excitotoxic damage makes it a compound of great interest in neuropharmacology. The diverse pharmacological effects of muscimol, from neuroprotection and pain relief to cognitive modulation and anticonvulsant properties, underscore its therapeutic potential across a range of neurological and psychiatric disorders ^[4]. Ongoing research continues to explore and expand upon the applications of muscimol in medicine.