Neural cell adhesion molecule

NCAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E3V, 2HAZ, 2VKW, 2VKX, 3MTR, 5AEA
Identifiers
Aliases	NCAM1, CD56, MSK39, NCAM, neural cell adhesion molecule 1
External IDs	OMIM: 116930; MGI: 97281; HomoloGene: 40754; GeneCards: NCAM1; OMA:NCAM1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.2 Start 112,961,247 bp[1] End 113,278,436 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.3|9 26.83 cM Start 49,413,436 bp[2] End 49,710,225 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence middle temporal gyrus entorhinal cortex corpus callosum endothelial cell Brodmann area 46 pons superior frontal gyrus prefrontal cortex Top expressed in Rostral migratory stream barrel cortex epithelium of lens substantia nigra neural layer of retina ventromedial nucleus iris fossa lateral hypothalamus ascending aorta More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 4684 17967 Ensembl ENSG00000149294 ENSMUSG00000039542 UniProt P13591 P13595 RefSeq (mRNA) NM_181351 NM_000615 NM_001076682 NM_001242607 NM_001242608 NM_001386289 NM_001386290 NM_001386291 NM_001386292 NM_001081445 NM_001113204 NM_010875 NM_001311065 RefSeq (protein) NP_000606 NP_001070150 NP_001229536 NP_001229537 NP_851996 NP_001074914 NP_001106675 NP_001297994 NP_035005 NP_001391651 Location (UCSC) Chr 11: 112.96 – 113.28 Mb Chr 9: 49.41 – 49.71 Mb PubMed search [3] [4]
Wikidata
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Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is mostly associated with, but not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells.^[5] NCAM has been implicated as having a role in cell–cell adhesion,^[6] neurite outgrowth, synaptic plasticity, and learning and memory.