Neuroblastoma RAS viral oncogene homolog

NRAS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CON, 2N9C
Identifiers
Aliases	NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, Neuroblastoma RAS viral oncogene homolog, NRAS proto-oncogene, GTPase
External IDs	OMIM: 164790; MGI: 97376; HomoloGene: 55661; GeneCards: NRAS; OMA:NRAS - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	114,716,771 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	102,975,230 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; epithelium of nasopharynx; ; secondary oocyte; ; amniotic fluid; ; mucosa of colon; ; mucosa of sigmoid colon; ; germinal epithelium; ; skin of thigh; ; ganglionic eminence; ; parietal pleura;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; lactiferous gland; ; sciatic nerve; ; yolk sac; ; ventricular zone; ; corneal stroma; ; epithelium of lens; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein-containing complex binding; GTP binding; GTPase activity; protein binding;
Cellular component	Golgi apparatus; membrane; Golgi membrane; plasma membrane; extracellular exosome; tertiary granule membrane;
Biological process	epidermal growth factor receptor signaling pathway; stimulatory C-type lectin receptor signaling pathway; MAPK cascade; axon guidance; Fc-epsilon receptor signaling pathway; Ras protein signal transduction; leukocyte migration; signal transduction; ERBB2 signaling pathway; neutrophil degranulation; positive regulation of endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4893
	18176
	ENSG00000213281
	ENSMUSG00000027852
	P01111
	P08556
	NM_002524
	NM_010937; NM_001368638
	NP_002515
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NRAS is an enzyme that in humans is encoded by the NRAS gene. It was discovered by a small team of researchers led by Robin Weiss at the Institute of Cancer Research in London.^[5]^[6] It was the third RAS gene to be discovered, and was named NRAS, for its initial identification in human neuroblastoma cells.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213281 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027852 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marshall CJ, Hall A, Weiss RA (September 1982). "A transforming gene present in human sarcoma cell lines". Nature. 299 (5879): 171–3. Bibcode:1982Natur.299..171M. doi:10.1038/299171a0. PMID 6287287. S2CID 4342747.
^ Shimizu K, Goldfarb M, Perucho M, Wigler M (January 1983). "Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line". PNAS. 80 (2): 383–7. Bibcode:1983PNAS...80..383S. doi:10.1073/pnas.80.2.383. PMC 393381. PMID 6300838.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213281 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027852 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6287287-5] Marshall CJ, Hall A, Weiss RA (September 1982). "A transforming gene present in human sarcoma cell lines". Nature. 299 (5879): 171–3. Bibcode:1982Natur.299..171M. doi:10.1038/299171a0. PMID 6287287. S2CID 4342747.

[pmid6300838-6] Shimizu K, Goldfarb M, Perucho M, Wigler M (January 1983). "Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line". PNAS. 80 (2): 383–7. Bibcode:1983PNAS...80..383S. doi:10.1073/pnas.80.2.383. PMC 393381. PMID 6300838.

[1]

[2]

[3]

[4]

[5]

[6]