Nitric oxide synthase 2 (inducible)

NOS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	OMIM: 163730; MGI: 97361; HomoloGene: 55473; GeneCards: NOS2; OMA:NOS2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	27,800,529 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,851,080 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; mucosa of transverse colon; ; rectum; ; appendix; ; testicle; ; prefrontal cortex; ; duodenum; ; right frontal lobe;
	Top expressed in
	Ileal epithelium; ; jejunum; ; muscle of thigh; ; placenta; ; thymus; ; entorhinal cortex; ; skeletal muscle tissue; ; esophagus; ; neural tube; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	FMN binding; protein homodimerization activity; flavin adenine dinucleotide binding; arginine binding; tetrahydrobiopterin binding; metal ion binding; calmodulin binding; protein binding; heme binding; oxidoreductase activity; signaling receptor binding; nitric-oxide synthase activity; NADPH-hemoprotein reductase activity; NADP binding;
Cellular component	cytoplasm; cytosol; cortical cytoskeleton; peroxisome; intracellular anatomical structure; perinuclear region of cytoplasm; nucleus; peroxisomal matrix; plasma membrane; vesicle membrane;
Biological process	positive regulation of guanylate cyclase activity; response to hypoxia; nitric oxide biosynthetic process; positive regulation of leukocyte mediated cytotoxicity; response to bacterium; negative regulation of protein catabolic process; regulation of insulin secretion; negative regulation of blood pressure; regulation of cytokine production involved in inflammatory response; positive regulation of killing of cells of other organism; negative regulation of gene expression; cell redox homeostasis; arginine catabolic process; prostaglandin secretion; response to lipopolysaccharide; innate immune response in mucosa; regulation of cell population proliferation; peptidyl-cysteine S-nitrosylation; defense response to bacterium; circadian rhythm; defense response to Gram-negative bacterium; nitric oxide mediated signal transduction; cellular response to interferon-gamma; regulation of cellular respiration; cellular response to lipopolysaccharide; superoxide metabolic process; cytokine-mediated signaling pathway; protein targeting to peroxisome; response to hormone;
	Sources:Amigo / QuickGO
Orthologs
	4843
	18126
	ENSG00000007171
	ENSMUSG00000020826
	P35228
	P29477
	NM_000625; NM_153292
	NM_010927; NM_001313921; NM_001313922
	NP_000616
	NP_001300850; NP_001300851; NP_035057
	Wikidata
View/Edit Human	View/Edit Mouse

Nitric oxide synthase, inducible is an enzyme which is encoded by the NOS2 gene in humans and mice.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007171 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020826 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, et al. (April 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3491–3495. Bibcode:1993PNAS...90.3491G. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007171 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020826 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7682706-5] Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, et al. (April 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3491–3495. Bibcode:1993PNAS...90.3491G. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706.

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