Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid[5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein.[6]
Because osteocalcin has gla domains, its synthesis is vitamin K dependent. In humans, osteocalcin is encoded by the BGLAP gene.[7][8] Its receptors include GPRC6A, GPR158, and possibly a third, yet-to-be-identified receptor.[9][10] There is evidence that GPR37 might be the third osteocalcin receptor.[11]
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