p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes,[5] though is primarily associated with inhibition of CDK2.[6][7] p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest.[8][9][10] This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.[11]
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