P21

CDKN1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U
Identifiers
Aliases	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A
External IDs	OMIM: 116899; MGI: 104556; HomoloGene: 333; GeneCards: CDKN1A; OMA:CDKN1A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 36,676,460 bp[1] End 36,687,339 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 15.12 cM Start 29,309,950 bp[2] End 29,319,701 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastric mucosa vena cava left uterine tube beta cell ascending aorta saphenous vein popliteal artery tibial arteries Descending thoracic aorta Top expressed in stroma of bone marrow calvaria molar pyloric antrum lip esophagus hair follicle epithelium of stomach skin of external ear endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding cyclin-dependent protein serine/threonine kinase inhibitor activity ubiquitin protein ligase binding cyclin binding cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein serine/threonine kinase activity protein kinase inhibitor activity protein kinase binding protein-containing complex binding Cellular component cytoplasm cytosol cyclin-dependent protein kinase holoenzyme complex PCNA-p21 complex perinuclear region of cytoplasm nucleus nucleoplasm nucleolus nuclear body protein-containing complex Biological process cellular response to extracellular stimulus signal transduction by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cellular response to heat regulation of cyclin-dependent protein serine/threonine kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of cell death response to organic cyclic compound negative regulation of cyclin-dependent protein serine/threonine kinase activity stress-induced premature senescence positive regulation of fibroblast proliferation replicative senescence response to hyperoxia response to corticosterone cellular response to amino acid starvation positive regulation of programmed cell death negative regulation of apoptotic process response to glucocorticoid response to arsenic-containing substance regulation of DNA biosynthetic process response to organic substance negative regulation of gene expression cellular response to DNA damage stimulus negative regulation of G1/S transition of mitotic cell cycle regulation of cell cycle intrinsic apoptotic signaling pathway cellular senescence positive regulation of reactive oxygen species metabolic process cellular response to UV-B G2/M transition of mitotic cell cycle positive regulation of B cell proliferation negative regulation of cell growth response to organonitrogen compound animal organ regeneration regulation of mitotic cell cycle intestinal epithelial cell maturation cellular response to ionizing radiation cell cycle Ras protein signal transduction negative regulation of phosphorylation response to toxic substance response to UV response to X-ray negative regulation of cell population proliferation protein stabilization positive regulation of cyclin-dependent protein kinase activity regulation of transcription by RNA polymerase II DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of protein kinase activity cellular response to gamma radiation negative regulation of cyclin-dependent protein kinase activity transcription initiation from RNA polymerase II promoter G1/S transition of mitotic cell cycle cytokine-mediated signaling pathway negative regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1026 12575 Ensembl ENSG00000124762 ENSMUSG00000023067 UniProt P38936 P39689 RefSeq (mRNA) NM_078467 NM_000389 NM_001220777 NM_001220778 NM_001291549 NM_001111099 NM_007669 RefSeq (protein) NP_000380 NP_001207706 NP_001207707 NP_001278478 NP_510867 NP_001361438 NP_001361439 NP_001361440 NP_001361441 NP_001361442 NP_001104569 NP_031695 Location (UCSC) Chr 6: 36.68 – 36.69 Mb Chr 17: 29.31 – 29.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

p21^Cip1 (alternatively p21^Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes,^[5] though is primarily associated with inhibition of CDK2.^[6][7] p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest.^[8][9][10] This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.^[11]