Parietal cell

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Parietal cell
A parietal cell.
Control of stomach acid
Details
Location	Stomach
Function	Gastric acid, intrinsic factor secretion
Identifiers
Latin	exocrinocytus parietalis
MeSH	D010295
TH	H3.04.02.1.00033
FMA	62901
Anatomical terms of microanatomy [edit on Wikidata]

Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach.^[1] They contain an extensive secretory network of canaliculi from which the HCl is secreted by active transport into the stomach. The enzyme hydrogen potassium ATPase (H⁺/K⁺ ATPase) is unique to the parietal cells and transports the H⁺ against a concentration gradient of about 3 million to 1,^{[citation needed]} which is the steepest^{[citation needed]} ion gradient formed in the human body. Parietal cells are primarily regulated via histamine, acetylcholine and gastrin signalling from both central and local modulators.