Pars compacta

Pars compacta
Pars compacta
Details
Part of	substantia nigra
Identifiers
Latin	pars compacta substantiae nigrae
Acronym(s)	SNpc
MeSH	D065842
NeuroLex ID	birnlex_990
TA98	A14.1.06.112
TA2	5882
FMA	62907
	Anatomical terms of neuroanatomy

The pars compacta (SNpc) is one of two subdivisions of the substantia nigra of the midbrain (the other being the pars reticulata); it is situated medial to the pars reticulata. It is formed by dopaminergic neurons.^[1] It projects to the striatum and portions of the cerebral cortex.^[2] It is functionally involved in fine motor control.

Parkinson's disease is characterized by the death of dopaminergic neurons in this region.^[1]

^ ^a ^b Kim, S. J.; Sung, JY; Um, JW; Hattori, N; Mizuno, Y; Tanaka, K; Paik, SR; Kim, J; Chung, KC (2003). "Parkin Cleaves Intracellular -Synuclein Inclusions via the Activation of Calpain". Journal of Biological Chemistry. 278 (43): 41890–9. doi:10.1074/jbc.M306017200. PMID 12917442.
^ Martin, John D. (2020). Neuroanatomy: Text and Atlas (5th ed.). New York: McGraw Hill. p. 309. ISBN 978-1-259-64248-7.

[:0-1] Kim, S. J.; Sung, JY; Um, JW; Hattori, N; Mizuno, Y; Tanaka, K; Paik, SR; Kim, J; Chung, KC (2003). "Parkin Cleaves Intracellular -Synuclein Inclusions via the Activation of Calpain". Journal of Biological Chemistry. 278 (43): 41890–9. doi:10.1074/jbc.M306017200. PMID 12917442.

[2] Martin, John D. (2020). Neuroanatomy: Text and Atlas (5th ed.). New York: McGraw Hill. p. 309. ISBN 978-1-259-64248-7.

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