Pericyclic reaction

Example of a pericycle reaction: the norcaradiene–cyclohexatriene rearrangement
Example of a pericycle reaction: the norcaradiene–cyclohexatriene rearrangement

In organic chemistry, a pericyclic reaction is the type of organic reaction wherein the transition state of the molecule has a cyclic geometry, the reaction progresses in a concerted fashion, and the bond orbitals involved in the reaction overlap in a continuous cycle at the transition state. Pericyclic reactions stand in contrast to linear reactions, encompassing most organic transformations and proceeding through an acyclic transition state, on the one hand and coarctate reactions, which proceed through a doubly cyclic, concerted transition state on the other hand. Pericyclic reactions are usually rearrangement or addition reactions. The major classes of pericyclic reactions are given in the table below (the three most important classes are shown in bold). Ene reactions and cheletropic reactions are often classed as group transfer reactions and cycloadditions/cycloeliminations, respectively, while dyotropic reactions and group transfer reactions (if ene reactions are excluded) are rarely encountered.

Name Bond changes
Sigma Pi
Electrocyclic reaction + 1 − 1
Cycloaddition (and cycloelimination) + 2 − 2
Sigmatropic reaction 0 0
Group transfer reaction 0 0
Ene reaction + 1 − 1
Cheletropic reaction + 2 − 1
Dyotropic reaction 0 0

In general, these are considered to be equilibrium processes, although it is possible to push the reaction in one direction by designing a reaction by which the product is at a significantly lower energy level; this is due to a unimolecular interpretation of Le Chatelier's principle. There is thus a set of "retro" pericyclic reactions.


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