Phosphatidylcholine transfer protein

PCTP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LN1, 1LN2, 1LN3
Identifiers
Aliases	PCTP, Pctp, PC-TP, StarD2, phosphatidylcholine transfer protein
External IDs	OMIM: 606055; MGI: 107375; HomoloGene: 32054; GeneCards: PCTP; OMA:PCTP - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	55,842,830 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	89,893,720 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right lobe of liver; ; right lung; ; monocyte; ; mucosa of transverse colon; ; placenta; ; sural nerve; ; rectum; ; blood; ; kidney tubule;
	Top expressed in
	left lobe of liver; ; yolk sac; ; lumbar spinal ganglion; ; skin of external ear; ; right kidney; ; stroma of bone marrow; ; lip; ; proximal tubule; ; human kidney; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylcholine transporter activity; phosphatidylcholine binding; lipid binding; phospholipid transporter activity;
Cellular component	cytoplasm; cytosol;
Biological process	phospholipid transport; lipid transport; phosphatidylcholine biosynthetic process; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	58488
	18559
	ENSG00000141179
	ENSMUSG00000020553
	Q9UKL6
	P53808; Q5SV41
	NM_001102402; NM_021213; NM_001330377; NM_001330378
	NM_008796; NM_001316372
	NP_001095872; NP_001317306; NP_001317307; NP_067036
	NP_001303301; NP_032822
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylcholine transfer protein (PCTP), also known as StAR-related lipid transfer domain protein 2 (STARD2), is a specific intracellular phospholipid binding protein that can transfer phosphatidylcholine between different membranes in the cytosol.^[5]^[6]

In humans, phosphatidylcholine transfer protein is encoded by the PCTP gene.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141179 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van Golde LM, Oldenborg V, Post M, Batenburg JJ, Poorthuis BJ, Wirtz KW (July 1980). "Phospholipid transfer proteins in rat lung. Identification of a protein specific for phosphatidylglycerol". J. Biol. Chem. 255 (13): 6011–3. doi:10.1016/S0021-9258(18)43688-5. PMID 7391000.
^ Wirtz KW (July 1991). "Phospholipid transfer proteins". Annu. Rev. Biochem. 60 (13): 73–99. doi:10.1146/annurev.bi.60.070191.000445. PMID 1883207.
^ "Entrez Gene: phosphatidylcholine transfer protein".
^ van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der Poll T, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP, Borst P (September 1999). "Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11501–6. Bibcode:1999PNAS...9611501V. doi:10.1073/pnas.96.20.11501. PMC 18063. PMID 10500206.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141179 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7391000-5] van Golde LM, Oldenborg V, Post M, Batenburg JJ, Poorthuis BJ, Wirtz KW (July 1980). "Phospholipid transfer proteins in rat lung. Identification of a protein specific for phosphatidylglycerol". J. Biol. Chem. 255 (13): 6011–3. doi:10.1016/S0021-9258(18)43688-5. PMID 7391000.

[pmid1883207-6] Wirtz KW (July 1991). "Phospholipid transfer proteins". Annu. Rev. Biochem. 60 (13): 73–99. doi:10.1146/annurev.bi.60.070191.000445. PMID 1883207.

[entrez-7] "Entrez Gene: phosphatidylcholine transfer protein".

[pmid10500206-8] van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der Poll T, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP, Borst P (September 1999). "Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11501–6. Bibcode:1999PNAS...9611501V. doi:10.1073/pnas.96.20.11501. PMC 18063. PMID 10500206.

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