Phosphoglycerate mutase

phosphoglycerate mutase 1 (brain)
Identifiers
Symbol	PGAM1
Alt. symbols	PGAMA
NCBI gene	5223
HGNC	8888
OMIM	172250
RefSeq	NM_002629
UniProt	P18669
Other data
EC number	5.4.2.11
Locus	Chr. 10 q25.3
Search for Structures Swiss-model Domains InterPro

This enzyme is not to be confused with Bisphosphoglycerate mutase which catalyzes the conversion of 1,3-bisphosphoglycerate to 2,3-bisphosphoglycerate.

Phosphoglycerate mutase (PGM) is any enzyme that catalyzes step 8 of glycolysis - the internal transfer of a phosphate group from C-3 to C-2 which results in the conversion of 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG) through a 2,3-bisphosphoglycerate intermediate. These enzymes are categorized into the two distinct classes of either cofactor-dependent (dPGM) or cofactor-independent (iPGM).^[1] The dPGM enzyme (EC 5.4.2.11) is composed of approximately 250 amino acids and is found in all vertebrates as well as in some invertebrates, fungi, and bacteria. The iPGM (EC 5.4.2.12) class is found in all plants and algae as well as in some invertebrate, fungi, and Gram-positive bacteria.^[2] This class of PGM enzyme shares the same superfamily as alkaline phosphatase.^[3]