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Polio vaccine

Polio vaccine
Vaccine description
TargetPoliomyelitis
Vaccine typeIPV: inactivated
OPV: attenuated
Clinical data
Trade namesIpol, Poliovax, others
AHFS/Drugs.comMonograph
MedlinePlusa601177
License data
Pregnancy
category
Routes of
administration		IPV: parenteral
OPV: oral
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
ChemSpider
  • None
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Polio vaccines are vaccines used to prevent poliomyelitis (polio).[2][3] Two types are used: an inactivated poliovirus given by injection (IPV) and a weakened poliovirus given by mouth (OPV).[2] The World Health Organization (WHO) recommends all children be fully vaccinated against polio.[2] The two vaccines have eliminated polio from most of the world,[4][5] and reduced the number of cases reported each year from an estimated 350,000 in 1988 to 33 in 2018.[6][7]

The inactivated polio vaccines are very safe.[2] Mild redness or pain may occur at the site of injection.[2] Oral polio vaccines cause about three cases of vaccine-associated paralytic poliomyelitis per million doses given.[2] This compares with 5,000 cases per million who are paralysed following a polio infection.[8] Both types of vaccine are generally safe to give during pregnancy and in those who have HIV/AIDS but are otherwise well.[2] However, the emergence of circulating vaccine-derived poliovirus (cVDPV), a form of the vaccine virus that has reverted to causing poliomyelitis, has led to the development of novel oral polio vaccine type 2 (nOPV2) which aims to make the vaccine safer and thus stop further outbreaks of cVDPV2.[9]

The first successful demonstration of a polio vaccine was by Hilary Koprowski in 1950, with a live attenuated virus which people drank.[10] The vaccine was not approved for use in the United States, but was used successfully elsewhere.[10] The success of an inactivated (killed) polio vaccine, developed by Jonas Salk, was announced in 1955.[2][11] Another attenuated live oral polio vaccine was developed by Albert Sabin and came into commercial use in 1961.[2][12]

Polio vaccine is on the World Health Organization's List of Essential Medicines.[13][14]

  1. ^ Use During Pregnancy and Breastfeeding
  2. ^ a b c d e f g h i World Health Organization (2016). "Polio vaccines: WHO position paper – March, 2016". Weekly Epidemiological Record. 91 (12): 145–68. hdl:10665/254399. PMID 27039410.
  3. ^ World Health Organization (2022). "Polio vaccines: WHO position paper – June 2022". Weekly Epidemiological Record. 97 (25): 277–300. hdl:10665/357168.
  4. ^ Aylward RB (2006). "Eradicating polio: today's challenges and tomorrow's legacy". Annals of Tropical Medicine and Parasitology. 100 (5–6): 401–413. doi:10.1179/136485906X97354. PMID 16899145. S2CID 25327986.
  5. ^ Schonberger LB, Kaplan J, Kim-Farley R, Moore M, Eddins DL, Hatch M (1984). "Control of paralytic poliomyelitis in the United States". Reviews of Infectious Diseases. 6 (Suppl 2): S424–S426. doi:10.1093/clinids/6.Supplement_2.S424. PMID 6740085.
  6. ^ "Global Wild Poliovirus 2014–2019" (PDF). Archived (PDF) from the original on 3 February 2019. Retrieved 3 February 2019.
  7. ^ "Does polio still exist? Is it curable?". World Health Organization (WHO). Archived from the original on 29 May 2018. Retrieved 21 May 2018.
  8. ^ "Poliomyelitis". World Health Organization (WHO). Archived from the original on 18 April 2017. Retrieved 25 April 2017.
  9. ^ "GPEI-nOPV2". Archived from the original on 27 July 2021. Retrieved 1 August 2021.
  10. ^ a b Fox M (20 April 2013). "Hilary Koprowski, Who Developed First Live-Virus Polio Vaccine, Dies at 96". The New York Times. Archived from the original on 25 August 2017. Retrieved 8 September 2017.
  11. ^ Bazin H (2011). Vaccination: A History. John Libbey Eurotext. p. 395. ISBN 978-2742007752. Archived from the original on 8 September 2017.
  12. ^ Smith DR, Leggat PA (2005). "Pioneering figures in medicine: Albert Bruce Sabin – inventor of the oral polio vaccine". The Kurume Medical Journal. 52 (3): 111–116. doi:10.2739/kurumemedj.52.111. PMID 16422178.
  13. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  14. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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