Surrounded by Boston's literary elite—which included friends such as Ralph Waldo Emerson, Henry Wadsworth Longfellow, and James Russell Lowell—Holmes made an indelible imprint on the literary world of the 19th century. Many of his works were published in The Atlantic Monthly, a magazine that he named. For his literary achievements and other accomplishments, he was awarded numerous honorary degrees from universities around the world. Holmes's writing often commemorated his native Boston area, and much of it was meant to be humorous or conversational. Some of his medical writings, notably his 1843 essay regarding the contagiousness of puerperal fever, were considered innovative for their time. He was often called upon to issue occasional poetry, or poems written specifically for an event, including many occasions at Harvard. Holmes also popularized several terms, including "Boston Brahmin" and "anesthesia".
Poe and his works influenced literature in the United States and around the world, as well as in specialized fields, such as cosmology and cryptography. Poe and his work appear throughout popular culture in literature, music, films, and television. A number of his homes are dedicated museums today.
Louisville is situated in north-central Kentucky on the Kentucky-Indiana border at the only natural obstacle in the Ohio River, the Falls of the Ohio. Although situated in a Southern state, Louisville is influenced by both Midwestern and Southern culture, and is commonly referred to as either the northernmost Southern city or the southernmost Northern city in the United States.
Louisville has been the site of many important innovations through history. Notable residents have included inventor Thomas Edison, the first Jewish Supreme Court Justice Louis Brandeis, boxing legend Muhammad Ali, newscaster Diane Sawyer, writer Hunter S. Thompson, and actor Tom Cruise. Notable events occurring in the city include the first public viewing place of Edison's light bulb, the first library open to African Americans in the South, and medical advances including the first human hand transplant, the first self-contained artificial heart transplant and the development site of the first cervical cancer vaccine.
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