Procaine benzylpenicillin

Procaine benzylpenicillin
Combination of
Benzylpenicillin	antibiotic
Procaine	anaesthetic
Clinical data
Trade names	Bicillin C-R, other
Other names	penicillin G procaine, procaine penicillin G, procaine penicillin
AHFS/Drugs.com	FDA Professional Drug Information
Routes of; administration	IM
ATC code	J01CE09 (WHO) QJ51CE09 (WHO);
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	54-35-3 ;
UNII	1LW5K9CIR1;
ChEMBL	ChEMBL1628385 ;
E number	E707 (antibiotics)
CompTox Dashboard (EPA)	DTXSID30883227 ;
ECHA InfoCard	100.000.187
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Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections.^[2] Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites.^[2] It is given by injection into a muscle.^[2]

Side effects include pain at the site of injection, blood clotting problems, seizures, and allergic reactions including anaphylaxis.^[2] When used to treat syphilis a reaction known as Jarisch-Herxheimer may occur.^[2] It is not recommended in those with a history of penicillin allergy or procaine allergy.^[1]^[2] Use during pregnancy and breastfeeding is relatively safe.^[1]^[2] Procaine benzylpenicillin is in the penicillin and beta lactam family of medications.^[2] It works via benzylpenicillin and results in bacterial death.^[2]^[3] Procaine makes the combination long acting.^[4]

Procaine benzylpenicillin was introduced for medical use in 1948.^[3] It is on the World Health Organization's List of Essential Medicines.^[5]

^ ^a ^b ^c ^d Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 95. ISBN 9781284057560.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 113, 607, 618. hdl:10665/44053. ISBN 9789241547659.
^ ^a ^b "Penicillin G Procaine - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 10 December 2016.
^ Ebadi, Manuchair (2007). Desk Reference of Clinical Pharmacology, Second Edition. CRC Press. p. 555. ISBN 9781420047448. Archived from the original on 2016-12-20.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.