Profadol

Profadol
Clinical data
ATC code	none;
Legal status
Legal status	US: Analogue to a Schedule I/II drug (Analogue of Tapentadol, Schedule II);
Identifiers
	IUPAC name 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol;
CAS Number	428-37-5;
PubChem CID	9882;
ChemSpider	9498;
UNII	41GDG43FTT;
ChEMBL	ChEMBL161204;
CompTox Dashboard (EPA)	DTXSID30861924 ;
Chemical and physical data
Formula	C14H21NO
Molar mass	219.328 g·mol−1

Profadol (CI-572) is an opioid analgesic which was developed in the 1960s by Parke-Davis.^[1] It acts as a mixed agonist-antagonist of the μ-opioid receptor. The analgetic potency is about the same as of pethidine (meperidine), the antagonistic effect is 1/50 of nalorphine.^[2]

^ DE 1303096
^ Schröder E, Rufer C, Schmiechen R (1976). Arzneimittelchemie 1. Grundlagen, Nerven, Muskeln und Gewebe. Stuttgart: Georg Thieme Verlag. ISBN 3-13-520601-7.

Clinical data

ATC code	none
Legal status
Legal status	US: Analogue to a Schedule I/II drug (Analogue of Tapentadol, Schedule II)
Identifiers
IUPAC name 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol
CAS Number	428-37-5
PubChem CID	9882
ChemSpider	9498
UNII	41GDG43FTT
ChEMBL	ChEMBL161204
CompTox Dashboard (EPA)	DTXSID30861924
Chemical and physical data
Formula	C₁₄H₂₁NO
Molar mass	219.328 g·mol⁻¹