Progressive massive fibrosis (PMF), characterized by the development of large conglomerate masses of dense fibrosis (usually in the upper lung zones), can complicate silicosis[1] and coal worker's pneumoconiosis.[2] Conglomerate masses may also occur in other pneumoconioses, such as talcosis,[3] berylliosis (CBD),[3] kaolin pneumoconiosis,[4] and pneumoconiosis from carbon compounds,[4] such as carbon black, graphite, and oil shale. Conglomerate masses can also develop in sarcoidosis,[5] but usually near the hilae and with surrounding paracicatricial emphysema.
The disease arises firstly through the deposition of silica or coal dust (or other dust) within the lung, and then through the body's immunological reactions to the dust.
- ^ Ziskind M, Jones RN and Weill H. Silicosis: State of the Art. Am Rev Resp Dis, 1976;113:643–665.
- ^ Hurley JF, Alexander WP, Hazledine DJ, Jacobsen M, Maclaren WM (October 1987). "Exposure to respirable coalmine dust and incidence of progressive massive fibrosis". British Journal of Industrial Medicine. 44 (10): 661–72. doi:10.1136/oem.44.10.661. PMC 1007898. PMID 3676119.
- ^ a b Chong S et al. Pneumoconiosis: Comparison of Imaging and Pathologic Findings. RadioGraphics, 2006;26:59-77.
- ^ a b Glazer CS and Newman LS. Occupational Interstitial Lung Disease. Clinics Chest Med, 2004;25:467–478.
- ^ Pipavath S and Godwin JD. Imaging of Interstitial Lung Disease. Clinics Chest Med, 2004;25:455–465.
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