Propylene glycol

Propylene glycol^[1]
ball-and-stick model	Space-filling model
Names
	Preferred IUPAC name Propane-1,2-diol
	Other names Propylene glycol; α-Propylene glycol; 1,2-Propanediol; 1,2-Dihydroxypropane; Methyl ethyl glycol; Methylethylene glycol;
Identifiers
CAS Number	57-55-6 racemic ; 4254-15-3 S-enantiomer;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16997 ;
ChEMBL	ChEMBL286398 ;
ChemSpider	13835224 ;
ECHA InfoCard	100.000.307
EC Number	200-338-0;
E number	E1520 (additional chemicals)
KEGG	C00583;
PubChem CID	1030;
RTECS number	TY6300000;
UNII	6DC9Q167V3 ; 942194N4TD (S-enantiomer) ;
CompTox Dashboard (EPA)	DTXSID0021206 ;
	InChI InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3 Key: DNIAPMSPPWPWGF-UHFFFAOYSA-N ;
	SMILES CC(O)CO;
Properties
Chemical formula	C3H8O2
Molar mass	76.095 g·mol−1
Appearance	colourless liquid
Odor	odorless
Density	1.036 g/cm3
Melting point	−59 °C (−74 °F; 214 K)
Boiling point	188.2 °C (370.8 °F; 461.3 K)
Solubility in water	Miscible
Solubility in ethanol	Miscible
Solubility in diethyl ether	Miscible
Solubility in acetone	Miscible
Solubility in chloroform	Miscible
log P	-1.34
Thermal conductivity	0.34 W/m-K (50% H2O @ 90 °C (194 °F))
Viscosity	0.042 Pa·s
Pharmacology
ATCvet code	QA16QA01 (WHO)
Hazards
NFPA 704 (fire diamond)	0 1 0
Related compounds
Related glycols	Ethylene glycol, 1,3-propanediol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Its chemical formula is CH₃CH(OH)CH₂OH. As it contains two alcohol groups, it is classed as a diol. It is miscible with a broad range of solvents, including water, acetone, and chloroform. In general, glycols^[5] are non-irritating and have very low volatility.^[6]

It is produced on a large scale primarily for the production of polymers. In the European Union, it has E-number E1520 for food applications. For cosmetics and pharmacology, the number is E490. Propylene glycol is also present in propylene glycol alginate, which is known as E405. Propylene glycol is a compound which is GRAS (generally recognized as safe) by the US Food and Drug Administration under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. Propylene glycol is approved and used as a vehicle for topical, oral, and some intravenous pharmaceutical preparations in the U.S. and in Europe.

^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. Merck & Co. 1989. ISBN 978-0911910285.
^ "Propylene Glycol_msds".
^ GHS: "Kein gefährlicher Stoff nach GHS" GESTIS 013620
^ "Propylene Glycol - Cameo Chemicals". NOAA Office of Response and Restoration. NOAA. Retrieved 3 October 2018.
^ Zapka, Maskrey (2016). Hawaii Energy and Environmental Technologies (HEET) Initiative.
^ Sullivan, Carl J.; Kuenz, Anja; Vorlop, Klaus-Dieter (2018). "Propanediols". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_163.pub2. ISBN 978-3527306732.

[1] The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. Merck & Co. 1989. ISBN 978-0911910285.

[chemsrc-2] "Propylene Glycol_msds".

[3] GHS: "Kein gefährlicher Stoff nach GHS" GESTIS 013620

[4] "Propylene Glycol - Cameo Chemicals". NOAA Office of Response and Restoration. NOAA. Retrieved 3 October 2018.

[5] Zapka, Maskrey (2016). Hawaii Energy and Environmental Technologies (HEET) Initiative.

[Ullmann-6] Sullivan, Carl J.; Kuenz, Anja; Vorlop, Klaus-Dieter (2018). "Propanediols". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_163.pub2. ISBN 978-3527306732.

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