Back سلفات البروتامين Arabic Sulfat de protamina Catalan Protamin German Sulfato de protamina Spanish پروتامین سولفات Persian Sulfate de protamine French Պրոտամին սուլֆատ Armenian Solfato di protamina Italian പ്രോട്ടാമിൻ‌ Malayalam ପ୍ରୋଟାମିନ ସଲଫେଟ OR

Protamine sulfate

Protamine sulfate
Clinical data
Trade namesProsulf, others
AHFS/Drugs.comMonograph
Routes of
administration		IV
Legal status
Legal status
Pharmacokinetic data
Onset of action5 minutes[2]
Identifiers
CAS Number
DrugBank
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.113.361 Edit this at Wikidata

Protamine sulfate is a medication that is used to reverse the effects of heparin.[3] It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery.[3][4] It is given by injection into a vein.[3] The onset of effects is typically within five minutes.[2]

Common side effects include low blood pressure, slow heart rate, allergic reactions, and vomiting.[3] Allergic reactions may be severe and include anaphylaxis.[3] The risk is greater in males who have had a vasectomy.[5] While there is no evidence of harm from using during pregnancy it has not been well studied in this group.[6] Protamine works by binding with heparin.[3]

Protamine sulfate was approved for medical use in the United States in 1969.[3] It is on the World Health Organization's List of Essential Medicines.[7] It was originally made from the sperm of salmon (salmine, salmon protamine).[3] It is now mainly made using recombinant biotechnology.[8]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ a b "Prosulf 10mg/ml Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
  3. ^ a b c d e f g h "Protamine Sulfate". The American Society of Health-System Pharmacists. Archived from the original on 6 November 2016. Retrieved 8 December 2016.
  4. ^ "Protamine sulfate". www.drugbank.ca. Retrieved 14 February 2019.
  5. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 255. hdl:10665/44053. ISBN 9789241547659.
  6. ^ "Protamine Use During Pregnancy". Drugs.com. Archived from the original on 21 December 2016. Retrieved 14 December 2016.
  7. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. ^ Kern MJ, Seto AR, Parise CM (2012). "Antithrombotic and Antiplatelet Therapy for Percutaneous Coronary Interventions". In Kern MJ (ed.). The Interventional Cardiac Catheterization Handbook E-Book. Elsevier Health Sciences. p. 131. ISBN 9781455740420.

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