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Pseudoautosomal region

Detail of a human metaphase spread. A region in the pseudoautosomal region of the short arms of the X chromosome (left) and the Y chromosome (top right) was detected by fluorescent in situ hybridization (green). Chromosomes counterstained in red.

The pseudoautosomal regions, PAR1, PAR2,[1] are homologous sequences of nucleotides on the X and Y chromosomes.

The pseudoautosomal regions get their name because any genes within them (so far at least 29 have been found for humans)[2] are inherited just like any autosomal genes. PAR1 comprises 2.6 Mbp of the short-arm tips of both X and Y chromosomes in humans and great apes (X and Y are 154 Mbp and 62 Mbp in total). PAR2 is at the tips of the long arms, spanning 320 kbp.[3]

  1. ^ Mangs, Helena; Morris BJ (2007). "The Human Pseudoautosomal Region (PAR): Origin, Function and Future". Current Genomics. 8 (2): 129–136. doi:10.2174/138920207780368141. PMC 2435358. PMID 18660847.
  2. ^ Blaschke RJ, Rappold G (2006). "The pseudoautosomal regions, SHOX and disease". Curr Opin Genet Dev. 16 (3): 233–9. doi:10.1016/j.gde.2006.04.004. PMID 16650979.
  3. ^ Helena Mangs A, Morris BJ (April 2007). "The Human Pseudoautosomal Region (PAR): Origin, Function and Future". Curr. Genomics. 8 (2): 129–36. doi:10.2174/138920207780368141. PMC 2435358. PMID 18660847.

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