Pyridoxine/doxylamine

Pyridoxine/doxylamine
Combination of
Pyridoxine	Vitamin
Doxylamine	Antihistamine
Clinical data
Trade names	Diclegis, Bendectin, Debendox, Lenotan, Merbental, Diclectin, others
Pregnancy; category	Compatible;
Routes of; administration	By mouth
Legal status
Legal status	CA: Approved; US: Approved; Prescription only; approved drug in Israel;
Identifiers
CAS Number	65-23-6 ; 469-21-6 ;
PubChem CID	163685;
ChemSpider	10750 ;
UNII	KV2JZ1BI6Z; 95QB77JKPL ;
KEGG	D10357;
	(verify)

Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B₆) and doxylamine succinate. It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.^[1]^[2]

^ Persaud N, Meaney C, El-Emam K, Moineddin R, Thorpe K (17 January 2018). "Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis". PLOS ONE. 13 (1): e0189978. Bibcode:2018PLoSO..1389978P. doi:10.1371/journal.pone.0189978. PMC 5771578. PMID 29342163.
^ Morning sickness drug Diclectin doesn't work, confidential industry documents reviewed by doctor show — Article published in "CBC news" on 17 January 2018

[Doxylamine-pyridoxine_for_nausea_an-1] Persaud N, Meaney C, El-Emam K, Moineddin R, Thorpe K (17 January 2018). "Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis". PLOS ONE. 13 (1): e0189978. Bibcode:2018PLoSO..1389978P. doi:10.1371/journal.pone.0189978. PMC 5771578. PMID 29342163.

[2] Morning sickness drug Diclectin doesn't work, confidential industry documents reviewed by doctor show — Article published in "CBC news" on 17 January 2018

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