Quasispecies model

The quasispecies model is a description of the process of the Darwinian evolution of certain self-replicating entities within the framework of physical chemistry. A quasispecies is a large group or "cloud" of related genotypes that exist in an environment of high mutation rate (at stationary state^[1]), where a large fraction of offspring are expected to contain one or more mutations relative to the parent. This is in contrast to a species, which from an evolutionary perspective is a more-or-less stable single genotype, most of the offspring of which will be genetically accurate copies.^[2]

It is useful mainly in providing a qualitative understanding of the evolutionary processes of self-replicating macromolecules such as RNA or DNA or simple asexual organisms such as bacteria or viruses (see also viral quasispecies), and is helpful in explaining something of the early stages of the origin of life. Quantitative predictions based on this model are difficult because the parameters that serve as its input are impossible to obtain from actual biological systems. The quasispecies model was put forward by Manfred Eigen and Peter Schuster^[3] based on initial work done by Eigen.^[4]

^ Eigen M, McCaskill J, Schuster P (1989). Molecular quasi-species. Vol. 92. John Wiley & Sons, Inc. pp. 6881–6891. doi:10.1021/j100335a010. hdl:11858/00-001M-0000-002C-84A7-C. ISBN 9780471622192. {{cite book}}: |journal= ignored (help)
^ Biebricher, C.K, Eigen, M. (2006). "What is a Quasispecies". In Esteban Domingo (ed.). Quasispecies: Concept and Implications for Virology. Springer. p. 1. ISBN 978-3-540-26395-1.
^ Eigen M, Schuster P (1979). The Hypercycle: A Principle of Natural Self-Organization. Berlin: Springer-Verlag. ISBN 978-0-387-09293-5.
^ Eigen M (October 1971). "Selforganization of matter and the evolution of biological macromolecules". Die Naturwissenschaften. 58 (10): 465–523. Bibcode:1971NW.....58..465E. doi:10.1007/BF00623322. PMID 4942363. S2CID 38296619.

[1] Eigen M, McCaskill J, Schuster P (1989). Molecular quasi-species. Vol. 92. John Wiley & Sons, Inc. pp. 6881–6891. doi:10.1021/j100335a010. hdl:11858/00-001M-0000-002C-84A7-C. ISBN 9780471622192. {{cite book}}: |journal= ignored (help)

[2] Biebricher, C.K, Eigen, M. (2006). "What is a Quasispecies". In Esteban Domingo (ed.). Quasispecies: Concept and Implications for Virology. Springer. p. 1. ISBN 978-3-540-26395-1.

[3] Eigen M, Schuster P (1979). The Hypercycle: A Principle of Natural Self-Organization. Berlin: Springer-Verlag. ISBN 978-0-387-09293-5.

[4] Eigen M (October 1971). "Selforganization of matter and the evolution of biological macromolecules". Die Naturwissenschaften. 58 (10): 465–523. Bibcode:1971NW.....58..465E. doi:10.1007/BF00623322. PMID 4942363. S2CID 38296619.

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