Race and genetics

Researchers have investigated the relationship between race and genetics as part of efforts to understand how biology may or may not contribute to human racial categorization. Today, the consensus among scientists is that race is a social construct, and that using it as a proxy for genetic differences among populations is misleading.[1][2]

Many constructions of race are associated with phenotypical traits and geographic ancestry, and scholars like Carl Linnaeus have proposed scientific models for the organization of race since at least the 18th century. Following the discovery of Mendelian genetics and the mapping of the human genome, questions about the biology of race have often been framed in terms of genetics.[3] A wide range of research methods have been employed to examine patterns of human variation and their relations to ancestry and racial groups, including studies of individual traits,[4] studies of large populations and genetic clusters,[5] and studies of genetic risk factors for disease.[6]

Research into race and genetics has also been criticized as emerging from, or contributing to, scientific racism. Genetic studies of traits and populations have been used to justify social inequalities associated with race,[7] despite the fact that patterns of human variation have been shown to be mostly clinal, with human genetic code being approximately 99.6%-99.9% identical between individuals, and with no clear boundaries between groups.[8][9][3]

Some researchers have argued that race can act as a proxy for genetic ancestry because individuals of the same racial category may share a common ancestry, but this view has fallen increasingly out of favor among experts.[2][10] The mainstream view is that it is necessary to distinguish between biology and the social, political, cultural, and economic factors that contribute to conceptions of race.[11][12]

Scientific consensus about race has shifted multiple times across history. In fact in the 1980s many scientists believed that there was a multiregional origin of different human races. It was not until 2003 that this theory was officially discarded in favor of the Out of Africa theory (OOA). [13] [14]

In 1956, some scientists proposed that race may be similar to dog breeds within dogs. However, this theory has since been discarded, with one of the main reasons being that dogs have been specifically bred artificially, whereas human races developed organically. [15] Furthermore, the genetic variation between dog breeds is far greater than that of human populations. Dog breed inter-variation is roughly 27.5%, whereas human populations inter-variation is only at 5.4%. [16]

Another similar erroneous analogy that popped up later on was the comparison of human races to subspecies among animals. Although human races can sometimes be mapped as gene clusters from DNA, there is still considerable overlap and similarities, whereas the same cannot necessarily be said for different subspecies. Therefore, it is statistically incorrect to insinuate that human races are comparable to subspecies. [17]

Race can be considered roughly a crude grouping based on superficial phenotypic attributes. The phenotypes may have a tangential connection to DNA, but are still yet a rough proxy that would omit various other genetic information. [18] In the past, it was common for race to be associated with IQ levels, with the justification being that supposedly, racial groupings were still statistically significant with regards to IQ. [19]However, this does not give much significant information - since the phenotypic traits used to assess someone's race are not representative of the specific genes that code for intelligence, for example. With intelligence being a polygenic trait like height, it is obvious that there would be statistical trends in arbitrary groupings such as race. Yet, these trends are still not an inherent quality of the phenotypes themselves, they are simply a rough measurement of gene clusters that can code for intelligence. As any gene, they can become more or less common within a population based on environmental factors - thus being an ambiguous construct altogether. [20]

Today, in a somewhat similar way that "gender" is differentiated from the more clear "biological sex", scientists state that potentially "race" / phenotypes can be differentiated from the more clear "ancestry".[21] However, this system has also still come under scrutiny as it may fall into the exact same problems - which would be large, vague groupings with little genetic value. [22]

  1. ^ Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Field (Consensus Study Report). National Academies of Sciences, Engineering, and Medicine. 2023. doi:10.17226/26902. ISBN 978-0-309-70065-8. PMID 36989389. In humans, race is a socially constructed designation, a misleading and harmful surrogate for population genetic differences, and has a long history of being incorrectly identified as the major genetic reason for phenotypic differences between groups.
  2. ^ a b "Researchers Need to Rethink and Justify How and Why Race, Ethnicity, and Ancestry Labels Are Used in Genetics and Genomics Research, Says New Report". National Academies of Sciences, Engineering, and Medicine. 14 March 2023. Researchers and scientists who utilize genetic and genomic data should rethink and justify how and why they use race, ethnicity, and ancestry labels in their work, says a new National Academies of Sciences, Engineering, and Medicine report. The report says researchers should not use race as a proxy for describing human genetic variation. Race is a social concept, but it is often used in genomics and genetics research as a surrogate for describing human genetic differences, which is misleading, inaccurate, and harmful.
  3. ^ a b Goodman, Alan H. (2020). Race : are we so different?. Yolanda T. Moses, Joseph L. Jones (Second ed.). Hoboken, NJ. ISBN 978-1-119-47247-6. OCLC 1121420797. Archived from the original on 2021-05-25. Retrieved 2021-04-08.{{cite book}}: CS1 maint: location missing publisher (link)
  4. ^ Jablonski, Nina G. (2006). Skin : a natural history. Berkeley: University of California Press. ISBN 0-520-24281-5. OCLC 64592114. Archived from the original on 2021-05-25. Retrieved 2021-04-08.
  5. ^ Rosenberg, Noah A.; Pritchard, Jonathan K.; Weber, James L.; Cann, Howard M.; Kidd, Kenneth K.; Zhivotovsky, Lev A.; Feldman, Marcus W. (2002-12-20). "Genetic structure of human populations". Science. 298 (5602): 2381–2385. Bibcode:2002Sci...298.2381R. doi:10.1126/science.1078311. ISSN 1095-9203. PMID 12493913. S2CID 8127224. Archived from the original on 2021-04-30. Retrieved 2021-04-08.
  6. ^ Lorusso, Ludovica; Bacchini, Fabio (August 2015). "A reconsideration of the role of self-identified races in epidemiology and biomedical research". Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences. 52: 56–64. doi:10.1016/j.shpsc.2015.02.004. PMID 25791919. Archived from the original on 2021-03-08. Retrieved 2021-04-08.
  7. ^ Saini, Angela (2019). Superior : the return of race science. Boston. ISBN 978-0-8070-7691-0. OCLC 1091260230. Archived from the original on 2021-08-08. Retrieved 2021-04-08.{{cite book}}: CS1 maint: location missing publisher (link)
  8. ^ Kidd, Kenneth (November 2004). "Implications of Biogeography of Human Populations for 'Race' and Medicine". Nature Genetics Supplement. 36 (11 Suppl): 22. doi:10.1038/ng1438. PMID 15507999.
  9. ^ Marks, Jonathan (2017). Is science racist?. Malden, MA. ISBN 978-0-7456-8921-0. OCLC 961801723. Archived from the original on 2021-05-02. Retrieved 2021-04-08.{{cite book}}: CS1 maint: location missing publisher (link)
  10. ^ Kaiser, Jocelyn (11 March 2023). "Geneticists should rethink how they use race and ethnicity, panel urges". Science.
  11. ^ "AABA Statement on Race & Racism". physanth.org.
  12. ^ Bamshad, Michael; Wooding, Stephen; Salisbury, Benjamin A.; Stephens, J. Claiborne (August 2004). "Deconstructing the relationship between genetics and race". Nature Reviews Genetics. 5 (8): 598–609. doi:10.1038/nrg1401. ISSN 1471-0056. PMID 15266342. S2CID 12378279. Archived from the original on 2021-06-10. Retrieved 2021-04-08.
  13. ^ Stringer, Chris (2002). "Modern human origins: progress and prospects". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 357 (1420): 563–579. doi:10.1098/rstb.2001.1057. PMC 1692961. PMID 12028792.
  14. ^ Stringer, Chris (May 2014). "Why we are not all multiregionalists now". Trends in Ecology and Evolution. 29 (5): 248–251. doi:10.1016/j.tree.2014.03.001. PMID 24702983.
  15. ^ Norton, Heather L.; Quillen, Ellen E.; Bigham, Abigail W.; Pearson, Laurel N.; Dunsworth, Holly (2019-07-09). "Human races are not like dog breeds: refuting a racist analogy". Evolution: Education and Outreach. 12 (1): 17. doi:10.1186/s12052-019-0109-y. ISSN 1936-6434.
  16. ^ "Genetics and the Shape of Dogs". American Scientist. 2017-02-06. Retrieved 2024-03-12.
  17. ^ "Race: The Power of an Illusion". www.racepowerofanillusion.org. Retrieved 2024-04-10.
  18. ^ www.nationalacademies.org https://www.nationalacademies.org/news/2023/03/researchers-need-to-rethink-and-justify-how-and-why-race-ethnicity-and-ancestry-labels-are-used-in-genetics-and-genomics-research-says-new-report. Retrieved 2024-03-12. {{cite web}}: Missing or empty |title= (help)
  19. ^ LiveScience, Megan Gannon. "Race Is a Social Construct, Scientists Argue". Scientific American. Retrieved 2024-03-12.
  20. ^ "Why experts recommend ditching racial labels in genetic studies". 2023-03-14. Retrieved 2024-03-12.
  21. ^ SITNFlash (2017-04-18). "How Science and Genetics are Reshaping the Race Debate of the 21st Century". Science in the News. Retrieved 2024-03-12.
  22. ^ Lewis, Anna C. F. (2022-05-02). "Substituting genetic ancestry for race in research? Not so fast". STAT. Retrieved 2024-03-12.

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