Renin

REN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XX4, 1BBS, 1BIL, 1BIM, 1HRN, 1RNE, 2BKS, 2BKT, 2FS4, 2G1N, 2G1O, 2G1R, 2G1S, 2G1Y, 2G20, 2G21, 2G22, 2G24, 2G26, 2G27, 2I4Q, 2IKO, 2IKU, 2IL2, 2REN, 2V0Z, 2V10, 2V11, 2V12, 2V13, 2V16, 2X0B, 3D91, 3G6Z, 3G70, 3G72, 3GW5, 3K1W, 3KM4, 3O9L, 3OAD, 3OAG, 3OOT, 3OQF, 3OQK, 3OWN, 3Q3T, 3Q4B, 3Q5H, 3SFC, 3VCM, 3VSW, 3VSX, 3VUC, 3VYD, 3VYE, 3VYF, 4AMT, 4GJ5, 4GJ6, 4GJ7, 4GJ8, 4GJ9, 4GJA, 4GJB, 4GJC, 4GJD, 4PYV, 4Q1N, 4RYC, 4RYG, 4RZ1, 4S1G, 4XX3
Identifiers
Aliases	REN, HNFJ2, renin, ADTKD4, RTD
External IDs	OMIM: 179820; MGI: 97898; HomoloGene: 20151; GeneCards: REN; OMA:REN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,154,819 bp[1] End 204,190,324 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua human kidney stromal cell of endometrium left ovary testicle right ovary renal cortex metanephros metanephric glomerulus body of uterus n/a More reference expression data BioGPS n/a
Gene ontology Molecular function insulin-like growth factor receptor binding aspartic-type endopeptidase activity endopeptidase activity peptidase activity signaling receptor binding hydrolase activity protein binding Cellular component cytoplasm membrane plasma membrane intracellular anatomical structure extracellular region extracellular space apical part of cell Biological process response to immobilization stress regulation of blood volume by renin-angiotensin male gonad development regulation of MAPK cascade kidney development renin-angiotensin regulation of aldosterone production cell maturation amyloid-beta metabolic process response to organic substance angiotensin maturation proteolysis mesonephros development regulation of blood pressure response to lipopolysaccharide protein catabolic process drinking behavior hormone-mediated signaling pathway response to cGMP response to cAMP Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5972 19701 Ensembl ENSG00000143839 ENSMUSG00000070645 UniProt P00797 P06281 RefSeq (mRNA) NM_000537 NM_031192 RefSeq (protein) NP_000528 NP_112469 Location (UCSC) Chr 1: 204.15 – 204.19 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that increases the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure.

Renin is not commonly referred to as a hormone, albeit it having a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below),^[4] as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I.