SOX2

SOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O4X, 2LE4
Identifiers
Aliases	SOX2, ANOP3, MCOPS3, SRY-box 2, Sox2, SRY-box transcription factor 2
External IDs	OMIM: 184429; MGI: 98364; HomoloGene: 68298; GeneCards: SOX2; OMA:SOX2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 181,711,925 bp[1] End 181,714,436 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 16.93 cM Start 34,704,554 bp[2] End 34,706,610 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone bronchial epithelial cell ganglionic eminence external globus pallidus pars reticulata dorsal motor nucleus of vagus nerve ventral tegmental area superior vestibular nucleus oral cavity subthalamic nucleus Top expressed in medial ganglionic eminence tooth germ Enamel organ Rostral migratory stream suprachiasmatic nucleus vestibular sensory epithelium ventricular zone lateral septal nucleus superior surface of tongue median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding miRNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription cis-regulatory region binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm cytosol transcription regulator complex nucleoplasm nucleus Biological process eye development pituitary gland development regulation of transcription, DNA-templated negative regulation of neuron differentiation somatic stem cell population maintenance endodermal cell fate specification positive regulation of cell-cell adhesion tissue regeneration negative regulation of transcription by RNA polymerase II chromatin organization transcription by RNA polymerase II regulation of cysteine-type endopeptidase activity involved in apoptotic process adenohypophysis development transcription, DNA-templated neuronal stem cell population maintenance positive regulation of transcription, DNA-templated multicellular organism development glial cell fate commitment response to wounding osteoblast differentiation positive regulation of cell differentiation negative regulation of epithelial cell proliferation regulation of gene expression inner ear development forebrain development response to growth factor negative regulation of canonical Wnt signaling pathway positive regulation of MAPK cascade positive regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway cell differentiation cell fate commitment central nervous system development neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6657 20674 Ensembl ENSG00000181449 ENSMUSG00000074637 UniProt P48431 P48432 RefSeq (mRNA) NM_003106 NM_011443 RefSeq (protein) NP_003097 NP_035573 Location (UCSC) Chr 3: 181.71 – 181.71 Mb Chr 3: 34.7 – 34.71 Mb PubMed search [3] [4]
Wikidata
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SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.^[5]

Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.^[5]

Sox2 holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.^[6]