Back معدل مستقبل الإستروجين الانتقائي Arabic Selektivní modulátor receptoru estrogenu Czech Selektiver Estrogenrezeptormodulator German Modulador selectivo de los receptores estrogénicos Spanish تعدیلکننده انتخابی گیرنده استروژن Persian Modulador selectivo do receptor de estróxeno Galician Modulatori selettivi del recettore degli estrogeni Italian 選択的エストロゲン受容体修飾薬 Japanese Селективни естрогенски рецепторни модулатори Macedonian Selectieve oestrogeenreceptormodulator Dutch
| Selective estrogen receptor modulator | |
|---|---|
| Drug class | |
 Tamoxifen, a nonsteroidal triphenylethylene antiestrogen and a widely used drug in the treatment of breast cancer. | |
| Class identifiers | |
| Synonyms | SERM; Estrogen receptor agonist/antagonist; ERAA |
| Use | Breast cancer, infertility, osteoporosis, vaginal atrophy, dyspareunia, contraception, male hypogonadism, gynecomastia, breast pain, others |
| ATC code | G03XC |
| Biological target | Estrogen receptor |
| Legal status | |
| In Wikidata | |
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonist/antagonists (ERAAs),[1][2] are a class of drugs that act on estrogen receptors (ER).[3] A characteristic that distinguishes these substances from pure ER agonists-antagonists (that is, full agonists and silent antagonists) is that their action is different in various tissues, allowing them to selectively inhibit or stimulate estrogen-like action in various tissues.
- ^ Hirsch HD, Shih E, Thacker HL (June 2017). "ERAAs for menopause treatment: Welcome the 'designer estrogens'". Cleve Clin J Med. 84 (6): 463–470. doi:10.3949/ccjm.84a.15140. PMID 28628428.
- ^ Archer DF (August 2020). "Ospemifene: less venous thrombosis than other selective estrogen receptor modulators in postmenopausal women with vulvo vaginal atrophy". Menopause. 27 (8): 846–847. doi:10.1097/GME.0000000000001600. PMID 32576803. S2CID 220045301.
- ^ Riggs BL, Hartmann LC (Feb 2003). "Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice". The New England Journal of Medicine. 348 (7): 618–29. doi:10.1056/NEJMra022219. PMID 12584371.
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