Selenium disulfide

Selenium disulfide
Clinical data
Trade names	Selseb, Selsun Blue, others
Other names	Selenium sulfide
AHFS/Drugs.com	Monograph
MedlinePlus	a682258
Routes of; administration	Topical
ATC code	D01AE13 (WHO) ;
Legal status
Legal status	AU: S5 (Caution); UK: P (Pharmacy medicines); US: OTC / Rx-only;
Identifiers
CAS Number	7488-56-4 ;
PubChem CID	24087;
DrugBank	DB00971;
ChemSpider	22519;
UNII	Z69D9E381Q;
KEGG	D05815;
ChEBI	CHEBI:135934;
ChEMBL	ChEMBL1200680;
ECHA InfoCard	100.028.458
Chemical and physical data
Formula	S2Se
Molar mass	143.09 g·mol−1
3D model (JSmol)	Interactive image;
Density	3 g/cm3
Melting point	111 °C (232 °F)
Boiling point	118 to 119 °C (244 to 246 °F) (decomposes)
Solubility in water	negligible mg/mL (20 °C)
	SMILES S=[Se]=S;
	InChI InChI=1S/S2Se/c1-3-2; Key:JNMWHTHYDQTDQZ-UHFFFAOYSA-N;

Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat seborrheic dermatitis, dandruff, and pityriasis versicolor.^[1]^[2] It is applied to the affected area as a lotion or shampoo.^[3] Symptoms frequently return if treatment is stopped.^[4]

Side effects may include hair discoloration, skin irritation, and risk of systemic absorption and toxicity, among others.^[1] Use is not recommended in children less than 2–5 years old.^[1]^[4] Use in pregnancy or breastfeeding has not been studied.^[5] It consists of a mixture of inorganic covalent compounds having an approximate empirical formulas of SeS₂.^[6] Selenium disulfide acts as a keratolytic and antifungal agent.^[7]^[8]^[9]

Selenium disulfide was approved for medical use in the United States at least as early as 1951.^[4] It is on the World Health Organization's List of Essential Medicines.^[10] Selenium disulfide is available as a generic medication and over the counter.^[3]

^ ^a ^b ^c World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 297. hdl:10665/44053. ISBN 9789241547659.
^ Cite error: The named reference pmid11702314 was invoked but never defined (see the help page).
^ ^a ^b Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 194. ISBN 9781284057560.
^ ^a ^b ^c "Selenium Sulfide". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
^ "Selenium sulfide topical Use During Pregnancy". Drugs.com. Archived from the original on 16 January 2017. Retrieved 13 January 2017.
^ Mitchell SC (2003). Biological Interactions Of Sulfur Compounds. CRC Press. p. 174. ISBN 9780203362525. Archived from the original on 16 January 2017.
^ Mitchell SC, Nickson RM, Waring RH (August 1993). "The Biological Activity of Selenium Sulfide". Sulfur Reports. 13 (2): 279–289. doi:10.1080/01961779308048957. eISSN 1029-0508. ISSN 0196-1772.
^ Borda LJ, Perper M, Keri JE (March 2019). "Treatment of seborrheic dermatitis: a comprehensive review". The Journal of Dermatological Treatment. 30 (2): 158–169. doi:10.1080/09546634.2018.1473554. PMID 29737895. S2CID 13686180.
^ Gupta AK, Madzia SE, Batra R (2004). "Etiology and management of Seborrheic dermatitis". Dermatology. 208 (2): 89–93. doi:10.1159/000076478. PMID 15056994. S2CID 22432032.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[WHO2008-1] World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 297. hdl:10665/44053. ISBN 9789241547659.

[pmid11702314-2] Cite error: The named reference pmid11702314 was invoked but never defined (see the help page).

[Ric2015-3] Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 194. ISBN 9781284057560.

[AHFS2017-4] "Selenium Sulfide". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.

[Drugs.com_pregnancy-5] "Selenium sulfide topical Use During Pregnancy". Drugs.com. Archived from the original on 16 January 2017. Retrieved 13 January 2017.

[6] Mitchell SC (2003). Biological Interactions Of Sulfur Compounds. CRC Press. p. 174. ISBN 9780203362525. Archived from the original on 16 January 2017.

[MitchellNicksonWaring1993-7] Mitchell SC, Nickson RM, Waring RH (August 1993). "The Biological Activity of Selenium Sulfide". Sulfur Reports. 13 (2): 279–289. doi:10.1080/01961779308048957. eISSN 1029-0508. ISSN 0196-1772.

[pmid29737895-8] Borda LJ, Perper M, Keri JE (March 2019). "Treatment of seborrheic dermatitis: a comprehensive review". The Journal of Dermatological Treatment. 30 (2): 158–169. doi:10.1080/09546634.2018.1473554. PMID 29737895. S2CID 13686180.

[pmid15056994-9] Gupta AK, Madzia SE, Batra R (2004). "Etiology and management of Seborrheic dermatitis". Dermatology. 208 (2): 89–93. doi:10.1159/000076478. PMID 15056994. S2CID 22432032.

[WHO21st-10] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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