Serotonin transporter

SLC6A4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I74
Identifiers
Aliases	SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR
External IDs	OMIM: 182138; MGI: 96285; HomoloGene: 817; GeneCards: SLC6A4; OMA:SLC6A4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 30,194,319 bp[1] End 30,236,002 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.18 cM Start 76,889,429 bp[2] End 76,923,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung jejunal mucosa lower lobe of lung placenta upper lobe of left lung duodenum superior vestibular nucleus oral cavity islet of Langerhans monocyte Top expressed in dorsal tegmental nucleus blood jejunum yolk sac duodenum set of raphe nuclei of tegmentum of midbrain adrenal gland intestinal villus secondary oocyte dorsal raphe nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cocaine binding nitric-oxide synthase binding protein homodimerization activity myosin binding syntaxin-1 binding metal ion binding neurotransmitter:sodium symporter activity actin filament binding monoamine transmembrane transporter activity protein binding symporter activity serotonin:sodium symporter activity dopamine:sodium symporter activity serotonin binding Cellular component integral component of membrane cytosol endosome membrane integral component of plasma membrane membrane raft neuron projection endosome membrane endomembrane system presynapse plasma membrane integral component of postsynaptic membrane integral component of presynaptic membrane serotonergic synapse focal adhesion synapse Biological process cellular response to organic substance cellular response to retinoic acid response to estradiol cellular response to cGMP response to hypoxia negative regulation of neuron differentiation ejaculation response to nutrient vasoconstriction negative regulation of cerebellar granule cell precursor proliferation memory monoamine transport response to organic substance brain development positive regulation of gene expression positive regulation of cell cycle serotonin transport protein complex oligomerization circadian rhythm transmembrane transport social behavior serotonin uptake neurotransmitter transport negative regulation of organ growth protein homooligomerization response to toxic substance negative regulation of synaptic transmission, dopaminergic brain morphogenesis positive regulation of serotonin secretion neurotransmitter biosynthetic process dopamine uptake involved in synaptic transmission regulation of thalamus size Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6532 15567 Ensembl ENSG00000108576 ENSMUSG00000020838 UniProt P31645 Q60857 RefSeq (mRNA) NM_001045 NM_010484 RefSeq (protein) NP_001036 NP_034614 Location (UCSC) Chr 17: 30.19 – 30.24 Mb Chr 11: 76.89 – 76.92 Mb PubMed search [3] [4]
Wikidata
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The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.^[5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake.^[6]

This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. Many antidepressant medications of the SSRI and tricyclic antidepressant classes work by binding to SERT and thus reducing serotonin reuptake.^[7] It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.^[8]