Sex hormone-binding globulin

Androgen-binding protein, Sex hormone-binding globulin
Androgen-binding protein, Sex hormone-binding globulin
Identifiers
Symbol	SHBG
Alt. symbols	ABP
NCBI gene	6462
HGNC	10839
OMIM	182205
RefSeq	NM_001040
UniProt	P04278
Other data
Locus	Chr. 17 p13-p12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

SHBG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LHW, 1D2S, 1F5F, 1KDK, 1KDM, 1LHN, 1LHO, 1LHU, 1LHV
Identifiers
Aliases	SHBG, ABP, SBP, TEBG, sex hormone binding globulin, Sex hormone-binding globulin
External IDs	OMIM: 182205; MGI: 98295; HomoloGene: 813; GeneCards: SHBG; OMA:SHBG - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,633,382 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,508,731 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; right testis; ; left testis; ; right adrenal cortex; ; duodenum; ; jejunal mucosa; ; left adrenal gland; ; left adrenal cortex; ; human kidney;
	Top expressed in
	morula; ; spermatocyte; ; embryo; ; Ileal epithelium; ; testicle; ; perirhinal cortex; ; entorhinal cortex; ; embryo; ; choroid plexus of fourth ventricle; ; CA3 field;
	More reference expression data
	More reference expression data
Orthologs
	6462
	20415
	ENSG00000129214
	ENSMUSG00000005202
	P04278
	P97497
NM_001040; NM_001146279; NM_001146280; NM_001146281; NM_001289113;
	NM_001289114; NM_001289115; NM_001289116
	NM_011367
NP_001031; NP_001139751; NP_001139752; NP_001139753; NP_001276042;
	NP_001276043; NP_001276044; NP_001276045
	NP_035497
	Wikidata
View/Edit Human	View/Edit Mouse

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. When produced by the Sertoli cells in the seminiferous tubules of the testis, it is called androgen-binding protein (ABP).^[5]^[6]

Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. SHBG is found in all vertebrates apart from birds.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005202 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bardin CW, Musto N, Gunsalus G, Kotite N, Cheng SL, Larrea F, Becker R (1981). "Extracellular androgen binding proteins". Annual Review of Physiology. 43: 189–98. doi:10.1146/annurev.ph.43.030181.001201. PMID 7011179.
^ Cite error: The named reference Hansson_1976 was invoked but never defined (see the help page).
^ Hammond GL (September 2011). "Diverse roles for sex hormone-binding globulin in reproduction". Biology of Reproduction. 85 (3): 431–41. doi:10.1095/biolreprod.111.092593. PMC 4480437. PMID 21613632.