T-box

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1h6f, 1xbr

T-box
T-box
	Crystallographic structure of the TBX3 protein dimer (cyan and green) complexed with DNA (brown) based on the PDB: 1h6f coordinates.
Identifiers
Symbol	T-box
Pfam	PF00907
InterPro	IPR001699
PROSITE	PS50252
SCOP2	1xbr / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1h6f, 1xbr

T-box refers to a group of transcription factors involved in embryonic limb and heart development.^[1] Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT.^[2]

^ Wilson V, Conlon FL (2002). "The T-box family". Genome Biology. 3 (6): REVIEWS3008. doi:10.1186/gb-2002-3-6-reviews3008. PMC 139375. PMID 12093383.
^ Müller, CW; Herrmann, BG (23 October 1997). "Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor". Nature. 389 (6653): 884–8. Bibcode:1997Natur.389..884M. doi:10.1038/39929. PMID 9349824. S2CID 13138577.

[pmid12093383-1] Wilson V, Conlon FL (2002). "The T-box family". Genome Biology. 3 (6): REVIEWS3008. doi:10.1186/gb-2002-3-6-reviews3008. PMC 139375. PMID 12093383.

[HermanMüller-2] Müller, CW; Herrmann, BG (23 October 1997). "Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor". Nature. 389 (6653): 884–8. Bibcode:1997Natur.389..884M. doi:10.1038/39929. PMID 9349824. S2CID 13138577.

[1]

[2]