TRPM8

TRPM8
Identifiers
Aliases	TRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
External IDs	OMIM: 606678; MGI: 2181435; HomoloGene: 23433; GeneCards: TRPM8; OMA:TRPM8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	234,019,522 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,317,015 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; prostate; ; pancreatic ductal cell; ; trigeminal ganglion; ; amniotic fluid; ; islet of Langerhans; ; endometrium; ; testicle; ; gallbladder; ; ganglionic eminence;
	Top expressed in
	seminiferous tubule; ; spinal ganglia; ; spermatid; ; cerebellar cortex; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; ion channel activity; protein binding; calcium channel activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; membrane raft; external side of plasma membrane; plasma membrane;
Biological process	response to stimulus; sensory perception of temperature stimulus; cellular calcium ion homeostasis; cation transport; ion transport; protein homotrimerization; response to cold; detection of temperature stimulus; protein homotetramerization; thermoception; calcium ion transport; response to temperature stimulus; transmembrane transport; calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	79054
	171382
	ENSG00000144481
	ENSMUSG00000036251
	Q7Z2W7
	Q8R4D5
	NM_024080
	NM_134252
	NP_076985
	NP_599013
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene.^[5]^[6] The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans.^[5]^[7] In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144481 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036251 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Andersen HH, Olsen RV, Møller HG, Eskelund PW, Gazerani P, Arendt-Nielsen L (March 2014). "A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia". European Journal of Pain. 18 (3): 315–25. doi:10.1002/j.1532-2149.2013.00380.x. PMID 23963768. S2CID 35385748.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^ Cite error: The named reference pmid 24664788 was invoked but never defined (see the help page).
^ Werkheiser JL, Rawls SM, Cowan A (October 2006). "Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats". European Journal of Pharmacology. 547 (1–3): 101–5. doi:10.1016/j.ejphar.2006.07.026. PMID 16945367.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144481 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036251 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid23963768-5] Andersen HH, Olsen RV, Møller HG, Eskelund PW, Gazerani P, Arendt-Nielsen L (March 2014). "A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia". European Journal of Pain. 18 (3): 315–25. doi:10.1002/j.1532-2149.2013.00380.x. PMID 23963768. S2CID 35385748.

[pmid16382100-6] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[pmid_24664788-7] Cite error: The named reference pmid 24664788 was invoked but never defined (see the help page).

[pmid16945367-8] Werkheiser JL, Rawls SM, Cowan A (October 2006). "Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats". European Journal of Pharmacology. 547 (1–3): 101–5. doi:10.1016/j.ejphar.2006.07.026. PMID 16945367.

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