TRPV1

TRPV1
Identifiers
Aliases	TRPV1, VR1, transient receptor potential cation channel subfamily V member 1
External IDs	OMIM: 602076; MGI: 1341787; HomoloGene: 12920; GeneCards: TRPV1; OMA:TRPV1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,609,411 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,152,068 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; sural nerve; ; apex of heart; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right uterine tube; ; gonad; ; left ovary; ; right ovary; ; canal of the cervix;
	Top expressed in
	lumbar spinal ganglion; ; trigeminal ganglion; ; morula; ; glossopharyngeal ganglion; ; blastocyst; ; embryo; ; spermatocyte; ; white adipose tissue; ; esophagus; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ion channel activity; phosphoprotein binding; ATP binding; cation transmembrane transporter activity; cation channel activity; ligand-gated ion channel activity; calcium-release channel activity; temperature-gated ion channel activity; identical protein binding; chloride channel regulator activity; transmembrane signaling receptor activity; excitatory extracellular ligand-gated ion channel activity; calcium channel activity; extracellular ligand-gated ion channel activity; phosphatidylinositol binding; metal ion binding; calmodulin binding; protein binding;
Cellular component	integral component of membrane; postsynaptic membrane; cell projection; membrane; plasma membrane; synapse; cell junction; dendritic spine membrane; cytosol; neuronal cell body; intrinsic component of plasma membrane; dendrite; external side of plasma membrane; neuron projection; integral component of plasma membrane; mitochondrion;
Biological process	ion transport; chemosensory behavior; cell surface receptor signaling pathway; calcium ion transmembrane transport; thermoception; calcium ion transport; inflammatory response; transmembrane transport; release of sequestered calcium ion into cytosol; negative regulation of transcription by RNA polymerase II; diet induced thermogenesis; detection of chemical stimulus involved in sensory perception of pain; microglial cell activation; cellular response to growth factor stimulus; positive regulation of gastric acid secretion; response to peptide hormone; cellular response to nerve growth factor stimulus; positive regulation of nitric oxide biosynthetic process; negative regulation of establishment of blood-brain barrier; lipid metabolism; temperature homeostasis; response to heat; cellular response to temperature stimulus; positive regulation of cytosolic calcium ion concentration; peptide secretion; detection of temperature stimulus involved in sensory perception of pain; sensory perception of mechanical stimulus; smooth muscle contraction involved in micturition; behavioral response to pain; response to pain; cellular response to alkaloid; cellular response to cytokine stimulus; fever generation; detection of temperature stimulus involved in thermoception; positive regulation of apoptotic process; urinary bladder smooth muscle contraction; glutamate secretion; sensory perception of pain; cellular response to tumor necrosis factor; cellular response to ATP; ion transmembrane transport; response to pH; response to organonitrogen compound; cellular response to heat; protein homotetramerization; excitatory postsynaptic potential; cellular response to acidic pH; response to capsazepine; calcium ion import across plasma membrane; negative regulation of systemic arterial blood pressure; negative regulation of heart rate; negative regulation of mitochondrial membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	7442
	193034
	ENSG00000196689
	ENSMUSG00000005952
	Q8NER1
	Q704Y3
	NM_018727; NM_080704; NM_080705; NM_080706
	NM_001001445
	NP_061197; NP_542435; NP_542436; NP_542437
	NP_001001445
	Wikidata
View/Edit Human	View/Edit Mouse

The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group.^[5]^[6] This protein is a member of the TRPV group of transient receptor potential family of ion channels.^[7] Fatty acid metabolites with affinity for this receptor are produced by cyanobacteria, which diverged from eukaryotes at least 2000 million years ago (MYA).^[8] The function of TRPV1 is detection and regulation of body temperature. In addition, TRPV1 provides a sensation of scalding heat and pain (nociception). In primary afferent sensory neurons, it cooperates with TRPA1^[9]^[10] (a chemical irritant receptor) to mediate the detection of noxious environmental stimuli.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005952 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (October 1997). "The capsaicin receptor: a heat-activated ion channel in the pain pathway". Nature. 389 (6653): 816–824. Bibcode:1997Natur.389..816C. doi:10.1038/39807. PMID 9349813. S2CID 7970319.
^ Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA (August 2001). "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants". Genomics. 76 (1–3): 14–20. doi:10.1006/geno.2001.6582. PMID 11549313.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^ McPartland JM (2004-04-01). "Phylogenomic and chemotaxonomic analysis of the endocannabinoid system". Brain Research Reviews. 45 (1): 18–29. doi:10.1016/j.brainresrev.2003.11.005. ISSN 0165-0173. PMID 15063097. S2CID 25038370.
^ Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (April 2015). "Structure of the TRPA1 ion channel suggests regulatory mechanisms". Nature. 520 (7548): 511–517. Bibcode:2015Natur.520..511P. doi:10.1038/nature14367. PMC 4409540. PMID 25855297.
^ Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D (September 2020). "Irritant-evoked activation and calcium modulation of the TRPA1 receptor". Nature. 585 (7823): 141–145. Bibcode:2020Natur.585..141Z. doi:10.1038/s41586-020-2480-9. PMC 7483980. PMID 32641835. S2CID 220407248.
^ Basbaum AI, Bautista DM, Scherrer G, Julius D (October 2009). "Cellular and molecular mechanisms of pain". Cell. 139 (2): 267–284. doi:10.1016/j.cell.2009.09.028. PMC 2852643. PMID 19837031.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196689 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005952 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Caterina_1997-5] Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (October 1997). "The capsaicin receptor: a heat-activated ion channel in the pain pathway". Nature. 389 (6653): 816–824. Bibcode:1997Natur.389..816C. doi:10.1038/39807. PMID 9349813. S2CID 7970319.

[pmid11549313-6] Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA (August 2001). "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants". Genomics. 76 (1–3): 14–20. doi:10.1006/geno.2001.6582. PMID 11549313.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[8] McPartland JM (2004-04-01). "Phylogenomic and chemotaxonomic analysis of the endocannabinoid system". Brain Research Reviews. 45 (1): 18–29. doi:10.1016/j.brainresrev.2003.11.005. ISSN 0165-0173. PMID 15063097. S2CID 25038370.

[9] Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (April 2015). "Structure of the TRPA1 ion channel suggests regulatory mechanisms". Nature. 520 (7548): 511–517. Bibcode:2015Natur.520..511P. doi:10.1038/nature14367. PMC 4409540. PMID 25855297.

[10] Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D (September 2020). "Irritant-evoked activation and calcium modulation of the TRPA1 receptor". Nature. 585 (7823): 141–145. Bibcode:2020Natur.585..141Z. doi:10.1038/s41586-020-2480-9. PMC 7483980. PMID 32641835. S2CID 220407248.

[11] Basbaum AI, Bautista DM, Scherrer G, Julius D (October 2009). "Cellular and molecular mechanisms of pain". Cell. 139 (2): 267–284. doi:10.1016/j.cell.2009.09.028. PMC 2852643. PMID 19837031.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]