Back تادالافيل Arabic تادالافيل ARZ تادافیل AZB Tadalafil Danish Tadalafil German Ταδαλαφίλη Greek Tadalafilo Spanish تادالافیل Persian Tadalafiili Finnish Tadalafil French
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| Clinical data | |
|---|---|
| Pronunciation | /təˈdæləfɪl/ tə-DAL-ə-fil |
| Trade names | Cialis, Adcirca, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a604008 |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Varies |
| Protein binding | 94% |
| Metabolism | Liver (predominantly CYP3A4) |
| Metabolites | Catechol metabolite |
| Onset of action | 30 minutes |
| Elimination half-life | 17.5 hours |
| Excretion | Feces (~61%), urine (~36%)[5] |
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| PDB ligand | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.214.024 |
| Chemical and physical data | |
| Formula | C22H19N3O4 |
| Molar mass | 389.411 g·mol−1 |
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Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.[5][6][8] It is taken by mouth.[8] Onset is typically within half an hour and the duration is up to 36 hours.[8]
Common side effects include headache, muscle pain, flushed skin, and nausea.[8] Caution is advised in those with cardiovascular disease.[8] Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss.[8] Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure.[8] Tadalafil is a PDE5 inhibitor which increases blood flow to the penis.[8] It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure.[8]
Tadalafil was approved for medical use in the United States in 2003.[8] It is available as a generic medication.[9] In 2021, it was the 171st most commonly prescribed medication in the United States, with more than 3 million prescriptions.[10][11]
- ^ "Tadalafil Use During Pregnancy". Drugs.com. 14 March 2019. Archived from the original on 1 December 2020. Retrieved 20 August 2020.
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- ^ Cite error: The named reference
Cialis tadalafil PIwas invoked but never defined (see the help page). - ^ "Cialis 10mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 26 April 2017. Archived from the original on 1 December 2020. Retrieved 20 August 2020.
- ^ a b c "Cialis- tadalafil tablet, film coated". DailyMed. 12 June 2020. Archived from the original on 21 September 2019. Retrieved 20 August 2020.
- ^ a b "Adcirca- tadalafil tablet". DailyMed. 23 June 2022. Archived from the original on 6 March 2023. Retrieved 10 April 2023.
- ^ "Cialis EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 7 January 2021. Retrieved 20 August 2020.
- ^ a b c d e f g h i j "Tadalafil Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 20 September 2020. Retrieved 8 April 2019.
- ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 796. ISBN 978-0-85711-338-2.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Tadalafil - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
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